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A number of amyloidogenic variants of apolipoprotein A-I (apoA-I) have been discovered but most have not been analyzed. Previously, we showed that the G26R mutation of apoA-I leads to increased β-strand structure, increased N-terminal protease susceptibility and increased fibril formation after several days of incubation. In vivo, this and other variants mutated in the N-terminal domain (residues
The use of food labels and packaging information on place of origin and credence quality has increased, but it is still unclear how such information relates to consumer decisions and choices concerning the relative valuation of attributes. Valid measurement methods are needed to assess the importance attributed by the public to such information, but also to inform the industry about market demand.
The International Federation of Nurse Anesthetists is improving anaesthesia patient care through a voluntary Anesthesia Program Approval Process (APAP) for schools and programmes. It is the result of a coordinated effort by anaesthesia leaders from many nations to implement a voluntary quality improvement system for education. These leaders firmly believe that meeting international education stand
Children developing type 1 diabetes may have risk markers already in their umbilical cord blood. It is hypothesized that the risk for type 1 diabetes at an early age may be increased by a pathogenic pregnancy and be reflected in altered cord-blood composition. In this study metabolomics was used to test if the cord-blood lipidome was affected in children diagnosed with type 1 diabetes before eight
Background/Aims: Obesity is a pervasive and highly prevalent disease that poses substantial health risks to those it affects. The rapid emergence of obesity as a global epidemic and the patterns and distributions of the condition within and between populations suggest that interactions between inherited biological factors (e.g. genes) and relevant environmental factors (e.g. diet and physical acti
The first generation of forest free-air CO2 enrichment (FACE) experiments has successfully provided deeper understanding about how forests respond to an increasing CO2 concentration in the atmosphere. Located in aggrading stands in the temperate zone, they have provided a strong foundation for testing critical assumptions in terrestrial biosphere models that are being used to project future intera
In the elderly, degenerative changes in the lumbar spine are common, contributing to falsely elevated bone mineral density (BMD) values. The parathyroid hormone (PTH) system plays an important role in the regulation of bone turnover and we explore the hypothesis that polymorphisms (SNPs) within genes in this pathway (PTH, PTHLH, PTH1R and PTH2R) contribute to degenerative manifestations of the spi
The pathogenesis of diabetic retinopathy (DR) remains unclear but hyperglycemia is an established risk factor. Endothelial dysfunction and changes in Ca(2+) signaling have been shown to precede the onset of DR. We recently demonstrated that high extracellular glucose activates the Ca(2+)/calcineurin-dependent transcription factor NFAT in cerebral arteries and aorta, promoting the expression of inf
Theorists of late modernity are discussing the effects of individualization on heterosexual couples. Processes of individualization are understood in terms of the individualized framework of thinking about self and others permeating Western societies. Sociological analyses of therapeutic manuals appoint them both as a symptom and as an effect of individualization processes. In popular therapy, Bec
Objective: The TEDDY Study is an international, multi-center prospective study designed to identify the environmental triggers of type 1 diabetes (T1D) in genetically at-risk children. This report investigates ethnic minority (EM) differences in patterns of enrollment and retention in the US centers. Methods: As of June 2009, 267,739 newborns had been screened at birth for high risk T1D genotypes.
Clinically relevant weight loss is achievable through lifestyle modification, but unintentional weight regain is common. We investigated whether recently discovered genetic variants affect weight loss and/or weight regain during behavioral intervention. Participants at high-risk of (Diabetes Prevention Program [DPP]; N=917/907 intervention/comparison) or with (Look AHEAD; N=2,014/1,892 interventio
Cocaine and amphetamine-regulated transcript (CART) is an islet peptide that promotes glucose stimulated insulin secretion in beta cells via cAMP/PKA-dependent pathways. In addition, CART is a regulator of neuronal survival. In this study, we examined the effect of exogenous CART 55-102 on beta cell viability and dissected its signaling mechanisms. Evaluation of DNA fragmentation and chromatin con
This study explores journalistic routines during the corona pandemic, with the aim of contributing to the hitherto sparse area of research focusing on the pandemics impact on journalism. Previous research emphasizes the complexity of news production and editorial work, and testifies to the variety of possible theoretical perspectives when studying journalistic routines. To enable a broader underst
Bakgrund: Covid-19-pandemin har förändrat utbildningsformen på universitet Sverige över, vilket påtvingat distansstudier för många studenter. Omställningen kan inverka på studenters upplevelse av aktivitetsbalans, vilket är kopplat med hälsa och välbefinnande, men det saknas idag studier inom detta fält. Ökad kunskap om hur studenter upplever distansundervisningens inverkan på deras aktivitetsbala
Offentlig upphandling är ett verktyg som har stor påverkan på marknaden på grund av dess stora köpkraft. EU vill använda den offentliga upphandlingen för att kunna uppnå en grön offentlig upphandling. EU antog 2010 en strategi som kallas för Europa 2020-strategin. Med den strategin bestämde sig EU för att uppnå vissa klimatmål. Grön offentlig upphandling skulle hjälpa till att uppnå de målen. Som Public procurement is a tool that has a major impact on the market due to its large purchasing power. The EU wants to use this tool to achieve a green public procurement. In 2010, the EU adopted a strategy called the Europe 2020 strategy. With that strategy, the EU committed to pursue certain climate goals. Green public procurement would help achieve those goals. As part of the strategy, a new dir
This thesis is placed in the context of talent management and revolves around the phenomena of talent and talent wars. The two phenomena have received increased attention in the talent management discourse during the last decades as the international competitiveness for talents among organizations has become amplified. The purpose of this thesis has been to explore, analyze and compare different p
Rätten att söka och åtnjuta asyl har fastställts genom FN:s allmänna förklaring om de mänskliga rättigheterna. Bedömningen av vem som anses vara flykting ska utföras i enlighet med kriterier och normer som återfinns inom internationell såväl som regional och nationell lagstiftning. I asylmål är det inte ovanligt med svårigheter att hitta bevis som styrker den sökandes utsaga. Istället läggs stor vThe right to seek refuge has been established by the the Universal Declaration of Human Rights. The rules and criteria which regulates the assessment of refugee claims can be found on an international, regional and national level. Lack of evidence is not an uncommon problem in refugee cases. Instead, credibility assessments becomes crucial. Well-functioning methods and criteria needs to be applied
