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Nutritional status provides metabolic substrates to activate AMP-Activated Protein Kinase (AMPK), the energy sensor that regulates metabolism. Recent evidence has demonstrated that AMPK has wider functions with respect to regulating immune cell metabolism and function. One such example is the regulatory role that AMPK has on NLRP3-inlflammasome and IL-1β biology. This in turn can result in subsequ
Allergic rhinitis (AR) poses a global health problem and can be challenging to treat. Many of the current symptomatic treatments for AR have been available for decades, yet there has been little improvement in patient quality of life or symptom burden over the years. In this review, we ask why this might be and explore the pathophysiological gaps that exist within the various AR treatment classes
A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8), which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited relatives of the identified carriers and showed that protection was associated with better insulin secretion due to enhanced glucose responsiveness and proinsulin conversion, particularly when compared with individual
The European Union (EU) has been entrusted with rather weak powers as regards industrial policy. On top of this, its Member States are prevented from pursuing a national industrial policy with monetary elements as this may distort competition within the EU internal market. At the same time, European companies compete in the global market with state-supported companies from other economically stron
OBJECTIVE: The aim of this study was to test the coherence of a wearable device, an inertial measurement unit (IMU) against the gold standard; also, to test the intra-trial reliability. This study has a cross-sectional design, where measurement of postural sway in the medio-lateral and anterior-posterior directions was performed simultaneously on a force plate and with a IMU called the Snubblomete
Multiplex proteomic platforms provide excellent tools for investigating associations between multiple proteins and disease (e.g., diabetes) with possible prognostic, diagnostic, and therapeutic implications. In this study our aim was to explore novel pathophysiological pathways by examining 92 proteins and their association with incident diabetes in a population-based cohort (146 cases of diabetes
The exegetical subjects have a particular interdisciplinary role within academia, implying that their responsibilities and significance are – and should be – under constant debate. In his article, church historian Joel Halldorf, argues for the overt use of theological interpretations (in the narrow sense of "normative theology") in the exegetical discipline. Halldorf thereby highlights some currenThe exegetical subjects have a particular interdisciplinary role within academia, implying that their responsibilities and significance are – and should be – under constant debate. In his article, church historian Joel Halldorf, argues for the overt use of theological interpretations (in the narrow sense of "normative theology") in the exegetical discipline. Halldorf thereby highlights some curren
The breaking with regime logics is one of the key leverage points to enable a socio-technical transition. Understanding how, and under what conditions, this may happen is thus an important task for transition studies. Recent research on socio-technical regimes has shown that they may be less geographically bound than previously assumed. Regimes may instead be replicated and reinforced globally thr
In this paper, we describe a new system to extract, index, search, and visualize entities in Wikipedia. To carry out the entity extraction, we designed a high-performance, multilingual, entity linker and we used a document model to store the resulting linguistic annotations. The entity linker, HEDWIG, extracts the mentions from text usinga string matching Engine and links them toentities with a co
The success of sustainable building renovation is inevitably dependent on the capabilities of the involved stakeholders throughout the entire project. Therefore, any building client with intentions of sustainable building renovations must reflect on sourcing the adequate capabilities for a sustainable renovation project. The question in focus is: how to facilitate a sourcing strategy for energy-ef
