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The grocery retail industry, with its large product volumes, low margins and fierce competition, is constantly seeking efficiency improvements in its supply chain. The grocery retail industry uses an immense amount of packaging and is directly affected by packaging logistics activities. There is, therefore, a potential for efficiency improvements in the grocery retail supply chain through the inte
The 16O(gamma,pn) reaction has been measured with a resolution high enough to resolve individual low-lying states in the residual 14N nucleus. The relative population of the states provides detailed information about the quantum numbers of the proton-neutron pairs on which photons are absorbed. Partial cross-sections, available to the acceptance of the detector system, have been extracted for the
“Diversify or die” is a recurring and rather dramatic call for organizations to recruit, retain and manage a demographically diverse workforce, advocated by the business case for diversity, also known as diversity management philosophy. Diversity management places diverse social identities at the heart of organizational success and has gained much attention from management consultants and managers
The human side of mergers and acquisitions (M&A) – with focus particularly on resistance - has puzzled scholars for decades. Still, there is little discussion as regards to how the concept should be defined or understood. Often expressions of resistance, rather than its actual content, are described. What do personnel actually oppose? In this dissertation, the content, process, and context of
The article examines the innovation-job quality-employment nexus in social and health care in the United Kingdom and Sweden, respectively. Through seven case studies carried out with a common methodological and analytical framework in the two countries, it shows how the constraining factors of fiscal strictures derived from budgetary regimes and chronic labor shortages have two key consequences fo
Genetic variants that inactivate protein-coding genes are a powerful source of information about the phenotypic consequences of gene disruption: genes that are crucial for the function of an organism will be depleted of such variants in natural populations, whereas non-essential genes will tolerate their accumulation. However, predicted loss-of-function variants are enriched for annotation errors,
This chapter approaches the process of spatial peripheralization from the perspective of concept-induced harm. Harm is both a moral and a legal term construed along any form of physical or mental damage, be it intended or unintended. More broadly, however, harm denotes any form of setback to interest, and while harm can arise as the result of an onset of emotion, more often than not harm is concep
Adaptive as well as innate immune responses contribute to the development of atherosclerosis. Studies performed in experimental animals have revealed that some of these immune responses are protective while others contribute to the progression of disease. These observations suggest that it may be possible to develop novel therapies for cardiovascular disease by selectively modulating such atheropr
The human Transient Receptor Potential A1 (hTRPA1) ion channel, also known as the wasabi receptor, acts as a biosensor of various potentially harmful stimuli. It is activated by a wide range of chemicals, including the electrophilic compound N-methylmaleimide (NMM), but the mechanism of activation is not fully understood. Here, we used mass spectrometry to map and quantify the covalent labeling in
The practice of using quantitative risk assessments (QRAs) for managing risks in land-use planning varies between countries. Some regulatory regimes are highly prescriptive in terms of explicit requirements on methodology, assumptions, modelling tools, input data, risk criteria, etc. Others require risk analyses to support decision-making without regulating the details. The present study seeks to
Type 2 diabetes (T2D) is a global public health challenge. Whilst the advent of genome-wide association studies has identified >400 genetic variants associated with T2D, our understanding of its biological mechanisms and translational insights is still limited. The EPIC-InterAct project, centred in 8 countries in the European Prospective Investigations into Cancer and Nutrition study, is one of th
Robustness is a prominent feature of most biological systems. Most previous related studies have been focused on homogeneous molecular networks. Here we propose a comprehensive framework for understanding how the interactions between genes, proteins and metabolites contribute to the determinants of robustness in a heterogeneous biological network. We integrate heterogeneous sources of data to cons
