Thioredoxin (Trx)-1 is a small, ubiquitously expressed redox-active protein with known important cytosolic functions. However, Trx1 is also upregulated in response to various stress stimuli, is found both at the cell surface and secreted into plasma, and has known anti-inflammatory and antiapoptotic properties. Previous animal studies have demonstrated that exogenous Trx1 delivery can have therape

Type 1 diabetes involves the specific destruction of the pancreatic islet β-cells, eventually resulting in a complete dependency of exogenous insulin. The clinical onset of diabetes is preceded by the appearance of autoantibodies against β-cell antigens. The human leukocyte antigen (HLA) region is the single most important genetic determinant of Type 1 diabetes susceptibility, yet variability in t

The deliberation that precedes or runs alongside the remaking of cities, buildings and landscapes seem almost by default to generate situations with unsatisfied stakehold-ers, neglected citizen groups or completely ignored voices. What does it mean to find, listen and respond to those concerned by alteration of built environments? Here, in this paper, citizen participation, its ideological and pol

High-fat diet-induced metabolic changes are not restricted to the onset of cardiovascular diseases, but also include effects on brain functions related to learning and memory. This study aimed to evaluate mitochondrial markers and function, as well as cognitive function, in a rat model of metabolic dysfunction. Eight-week-old male Wistar rats were subjected to either a control diet or a two-hit pr

Intervention with Mediterranean diet (MedDiet) has provided a high level of evidence in primary prevention of cardiovascular events. Besides enhancing protection from classical risk factors, an improvement has also been described in a number of non-classical ones. Benefits have been reported on biomarkers of oxidation, inflammation, cellular adhesion, adipokine production, and pro-thrombotic state

RNA editing is a post-transcriptional alteration of RNA sequences that, via insertions, deletions or base substitutions, can affect protein structure as well as RNA and protein expression. Recently, it has been suggested that RNA editing may be more frequent than previously thought. A great impediment, however, to a deeper understanding of this process is the paramount sequencing effort that needs

This paper examines how governance structures found in the trucking industry impact the coordination between a forwarder and its carriers, including three cases: no forwarder coordination (direct contracting with shippers), investor-owned coordination (price-only contract), and carrier-cooperative coordination (revenue-sharing contract). The carriers are engaged in a Cournot competition, where the

Cyanobacteria in fresh water can cause serious threats to drinking water supplies. Managing cyanobacterial blooms particularly at small drinking water treatment plants is challenging. Because large amount of cyanobacteria may cause clogging in the treatment process and various cyanotoxins are hard to remove, while they may cause severe health problems. There is lack of instructions of what cyanoba

Improving electrical efficiency has been proposed as the most convenient means of reducing, e.g. CO2 emission from power plants. Increasing fuel utilization through combined heat and power generation is another useful measure for emission reduction. Trigeneration technology for the production of heat, power and cooling is an interesting alternative for further improvement of fuel utilization. Prev

En podd om undergången kan få oss att tänka på framtiden Hur vi påverkas av att ta del av berättelser om en dyster framtid skiljer sig åt. Hos vissa väcks ett driv att se till så att det inte går fullt så illa. Men det kan också få en att känna att allt är kört och att vi lika gärna kan ge upp. Vad gör det med oss att föreställa oss att vi inte kan stoppa klimatförändringarna? Och att vår planet

I den här studien undersöks hur fem musiklärare som är, eller har varit, verksamma i anpassad grundskola beskriver hur de arbetar med musikalisk kunskapsutveckling, delaktighet och måluppfyllelse. Undersökningen baseras på semistrukturerade intervjuer och hela arbetet vilar på socialkonstruktivismen som vetenskapsteori. Ämnesvalet grundar sig i en nyfikenhet kring hur vi som framtida lärare kan ar

Social isolation and loneliness among older adults are growing public health concerns. Although information and communication technologies (ICT) are increasingly promoted to foster social connectedness, how older adults perceive and adopt these technologies remains underexplored. This study applies the Unified Theory of Acceptance and Use of Technology (UTAUT) to examine ICT engagement among older