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Aim and objective. The aim was to explore empowerment within the patient-staff encounter as experienced by out-patients with chronic kidney disease. Background. Empowerment has an important role to play in the patient-staff relationship in the case of patients with a chronic disease. When it comes to patients with chronic kidney disease, there has been little research on empowerment, for which rea
Objective: Type 2 diabetes is heterogeneous in its clinical features, pathogenesis, and predisposing or causal genetic factors. This report examines what is known and what needs to be learned about the potential to individualize glycemic therapies in type 2 diabetes, based on phenotypes and genotypes. Participants: A 29-member international working group with expertise in diabetes epidemiology, ph
BACKGROUND: Suicide attempts have been shown to be less common in older age groups, with repeated attempts generally being more common in younger age groups and severe attempts in older age groups. Consistently, most studies have shown an increased suicide risk after attempts in older age. However, little is known about the predictive value of age on repeated and severe suicide attempts for accomp
Aim: To present gender-specific normative data on estimates of neuromuscular performance, such as muscle strength, vertical jump and standing unilateral balance, in pre-pubertal children. Methods: Lean body mass (kg) and fat mass (%) were estimated by dual-energy X-ray absorptiometry in 246 boys and 190 girls aged 6-12 years in Tanner stages 1 and 2. Isokinetic concentric peak torque at 60 and 180
Aims: This study summarises the health-related quality of life (HRQOL) scores and absenteeism caused by sinus problems in patients awaiting surgery with the diagnoses recurrent acute rhinosinusitis (RARS), chronic rhinosinusitis with nasal polyps (CRS+NP) or CRS without nasal polyps (CRS-NP), in a prospective multi-centre study. Methodology: Two hundred and seven patients with RARS, CRS+NP or CRS-
Drugs acting on the central nervous system (CNS) and given to a pregnant woman during the latter part of pregnancy may affect neonatal morbidity of the infant. Little is known on the combined effects of different categories of such drugs. The redeeming of prescriptions for CNS-active drugs during the second or third trimester of pregnancy was studied by linkage between a register of prescribed dru
Small vessel disease (SVD) and amyloid deposition may promote each other, with a potential association between SVD and altered production or clearance of β-amyloid (Aβ) affecting its cleavage products. We investigated the relationship between SVD, multiple isoforms of Aβ in cerebrospinal fluid (CSF) and cortical Aβ in 831 subjects with cognitive performance ranging from normal to Alzheimer's disea
Apolipoprotein A-I (apoA-I) is the major protein component of high density lipoproteins (HDL) and plays a central role in cholesterol metabolism. The lipid-free/lipid-poor form of apoA-I is the preferred substrate for the ATP-binding cassette transporter A1 (ABCA1). The interaction of apoA-I with ABCA1 leads to the formation of cholesterol laden high density lipoprotein (HDL) particles, a key step
BACKGROUND: Hormone-sensitive lipase (HSL) is a key enzyme in the mobilization of energy in the form of fatty acids from intracellular stores of neutral lipids. The enzyme has been shown to exist in different isoforms with different molecular masses (84 kDa, 89 kDa and 117 kDa) expressed in a tissue-dependent manner, where the predominant 84 kDa form in adipocytes is the most extensively studied.
Abstract The aim was to evaluate if the Dried Blood Spot (DBS)-technique can be used to analyse C-peptide. S-C-peptide and paired whole blood clotted on filters, dried, punched out and eluted were sampled from 198 healthy subjects. Six subjects with S-C-peptide values outside the reference range were excluded. A conversion formula using log-DBS-C-peptide was generated in a subset of 156 ( approxim
Diabetic kidney disease is the leading cause of end-stage renal disease. Genetic factors have been suggested to contribute to its susceptibility. However, results from genetic studies are disappointing possibly because the role of glucose in diabetic kidney disease predisposed by epigenetic mechanisms has not been taken into account. Since thioredoxin-interacting protein (TXNIP) has been shown to
The move towards the liberalisation of the energy markets in the whole world and the general shift from command-and-control to market mechanisms bring forward new ways of stimulating initiatives to increase the efficiency in the final uses of energy and demand-side management. In the past, energy policies were implemented in most countries by direct action of the governments through state monopoli
The importance of load demand variation, when analysing energy and environmental impact of residential energy use, is increasing. Load demand in residential houses is a significant contributor to peak load problems experienced by utilities. The knowledge about demand variation in households is limited as well as the use of methodologies to analyse the demand is. Many utilities have recently instal
The paper describes measurements performed in three district heating (DH) substations in semidetached houses. In all these houses more than 40 % of the domestic hot water (DHW) tappings turned out to be shorter than 10 s. The fraction of total energy used to heat this water varied between 2.4 % and 10.2 %, indicating a large influence of households' daily habits. For 60-78 % of tappings, the total
Since year 2000 a number of national energy management systems (EnMS) standards and specifications have been developed. To support EnMS implementation in industry some governments have launched agreements centered around energy management practices. National experiences show that such policy programs can achieve significant energy efficiency improvements. Implementation of industrial EnMSs has gra
