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Shared genetic factors involved in celiac disease, type 2 diabetes and anorexia nervosa suggest common molecular pathways for chronic diseases

Background and Objectives: Genome-wide association studies (GWAS) have identified several genetic regions involved in immune-regulatory mechanisms to be associated with celiac disease. Previous GWAS also revealed an over-representation of genes involved in type 2 diabetes and anorexia nervosa associated with celiac disease, suggesting involvement of common metabolic pathways for development of the

ISL1 is a major susceptibility gene for classic bladder exstrophy and a regulator of urinary tract development

Previously genome-wide association methods in patients with classic bladder exstrophy (CBE) found association with ISL1, a master control gene expressed in pericloacal mesenchyme. This study sought to further explore the genetics in a larger set of patients following-up on the most promising genomic regions previously reported. Genotypes of 12 markers obtained from 268 CBE patients of Australian,

Risk of other Cancers in Families with Melanoma : Novel Familial Links

A family history of cutaneous melanoma ('melanoma') is a well-established risk factor for melanoma. However, less is known about the possible familial associations of melanoma with other discordant cancers. A risk for discordant cancer may provide useful information about shared genetic and environmental risk factors and it may be relevant background data in clinical genetic counseling. Using the

Age-specific Trends in Incidence, Mortality and Comorbidities of Heart Failure in Denmark 1995-2012

BACKGROUND—: The cumulative burden and importance of cardiovascular risk factors have changed over the last decades. Specifically, obesity rates have increased among younger people, whereas cardiovascular health has improved in the elderly. Little is known regarding how these changes have impacted the incidence and the mortality rates of heart failure. Therefore, we aimed to investigate the age-sp

Diagnostic agreement and interobserver concordance with teledermoscopy referrals

Background: Malignant melanoma and non-melanoma skin cancers are among the fastest increasing malignancies in many countries. With the help of new tools, such as teledermoscopy referrals between primary health care and dermatology clinics, the management of these patients could be made more efficient. Objective: To evaluate the diagnostic agreement and interobserver concordance achieved when asses

Social Support, Socio-Economic Status, Health and Abuse among Older People in Seven European Countries

Background: Social support has a strong impact on individuals, not least on older individuals with health problems. A lack of support network and poor family or social relations may be crucial in later life, and represent risk factors for elder abuse. This study focused on the associations between social support, demographics/socio-economics, health variables and elder mistreatment. Methods: The c

Investigation of chlorinated solvent pollution with resistivity and induced polarization

Globally, an enormous number of polluted areas are in need of remediation to prevent adverse effects on health and environment. In situ remediation and especially the monitoring thereof needs further development to avoid costly and hazardous shipments associated with excavation. The monitoring of in situ remediation actions needs easier and cheaper nondestructive methods for evaluation and verific

Using Controlled Active Mass (CAM) to decrease energy demand for cooling

Overheating in summer is a problem in buildings with large glass area and low heat capacity constructive materials. Adding some thermal mass to the building is a way to overcome this problem. A new method is using removable thermal mass. This is called Controlled Active Mass (CAM). The CAM is an extra thermal mass which is placed inside the building to decrease energy demand for cooling and heatin

Assessment of value for resource allocation in cancer care

There has been an increased interest in ways of measuring the value of new therapeutic options in oncology. An example of this in a European context is the ESMO Magnitude of Clinical Benefit Scale (ESMO-MCBS). The purpose of this study is to analyse how the value scales, exemplified with ESMO-MCBS, developed mainly to assist decisions by physicians, relate to other measures of clinical benefit and

Measuring motivation using the transtheoretical (stages of change) model : A follow-up study of people who failed an online hearing screening

Abstract: Objective: Acceptance and readiness to seek professional help have shown to be important factors for favourable audiological rehabilitation outcomes. Theories from health psychology such as the transtheoretical (stages-of-change) model could help understand behavioural change in people with hearing impairment. In recent studies, the University of Rhode Island change assessment (URICA) ha

Josef Bexell som själasörjare

Josef Bexell as soul-carer Josef Bexell (1815–1897), Lutheran rector of Långaryd in the diocese of Växjö, was widely known as a soul-carer, both in public and in private. His sermons were not only heard in Church, but circulated and read in private, and questions from his private soul-care were answered in public preaching. The private soul-care was performed both in private encounters and in lett

Reduced global warming potential after wood ash application in drained Northern peatland forests

Past land use change has converted vast areas of Northern peatland by drainage to agricultural or forested land. This change often reduces the greenhouse gas (GHG) sink strength of peatlands or turns them even from sinks to sources, which affects the global climate. Therefore, there is a need for suitable mitigation options for GHG emissions from drained peatlands. Addition of wood ash to peatland

Optimization of opportunistic replacement activities: A case study in the aircraft industry

In the aircraft industry maximizing availability is essential. Maintenance schedules must therefore be opportunistic, incorporating preventive maintenance activities within the scheduled as well as the unplanned ones. At the same time, the maintenance contractor should utilize opportunistic maintenance to enable the minimization of the total expected cost to have a functional aircraft engine and t

How to make a workplace health promotion questionnaire process applicable, meaningful and sustainable.

How to make a workplace health promotion questionnaire process applicable, meaningful and sustainable Background In workplace health promotion, a questionnaire could be of great use. Unfortunately, fatigue regarding answering questionnaires has recently become greater than before. An action research approach could be a possible way of increasing employee participation. Aim This study reports an at

Contentious Politics Studies : Forskningsfältet social och politisk konfrontation på frammarsch i Skandinavien

In the last decade or so an increasing number of researchers in Scandinavia have become interested in the research field of contentious politics studies (CPS). The result has been a growing number of publications focusing on political contention. We have now reached the point where international research networks are being set up. Several interesting workshops and book projects are underway unders