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Changes of cellular metabolism are an integral property of the malignant potential of most cancer cells. Already in the 1930s, Otto Warburg observed that tumor cells preferably utilize glycolysis and lactate fermentation for energy production, rather than the mitochondrial oxidative phosphorylation dominating in normal cells, a phenomenon today known as the Warburg effect. Even though many tumor t
Objective: Postprandial hyperlipemia, characterized by increased circulating very low-density lipoproteins (VLDL) and circulating lipopolysaccharide (LPS), has been proposed as a mechanism of vascular injury. Our goal was to examine the interactions between postprandial lipoproteins, LPS, and apoE3 and apoE4 on monocyte activation. Methods and Results: We showed that apoE3 complexed to phospholipi
Directive 2008/96/EC on road infrastructure safety management requires the establishment and implementation of procedures relating to road safety impact assessments (RSIA), road safety audits (RSA), ranking of high accident concentration sections and network safety ranking (NSR) and road safety inspections (RSI). The aim of this article is to present the outputs of BALTRIS project. The goal of the
Objectives. To investigate the caries risk profiles in young adults and to compare the risk classification using the Public Dental Service (PDS) guidelines with a risk assessment program, the Cariogram. Materials and methods. All 19-year-old patients registered at eight public dental clinics were invited to participate (n = 1699). The study group who completed the baseline examination consisted of
Reforestation of ex-arable land in temperate regions increases the area of potential habitat for forest plants. However, the herbaceous plant layer of these plantations contains fewer forest species than comparable plantations at continuously forested sites. One of the reasons for this might be differences in recruitment. The present study addresses post-dispersal seed predation, mainly of woody p
Assessment of the potential impact of climate change on water systems has been an essential part of hydrological research over the last couple of decades. However, the notion that such assessments should also include technological, demographic and land use changes is relatively recent. In this study, the potential impacts of climate change and continued urbanisation on waste and stormwater flows i
Systemic glucose homeostasis is profoundly influenced by adipose cell function. Here we investigated GLUT4 dynamics in living adipose cells from human subjects with varying BMI and insulin sensitivity index (S-i) values. Cells were transfected with hemagglutinin (HA)-GLUT4-green fluorescent protein (GFP)/mCherry (red fluorescence), and were imaged live using total internal reflection fluorescence
Background: Teamwork is a standard of care in palliative care and that is emphasized by leading organizations. When interdisciplinary teams communicate their varied assessments, outcomes may be more than additive due to the synthesis of information. Interprofessionality does not guarantee multidimensionality in health care interventions, however, and that interprofessional teams promote collaborat
Local adaptation is an important process contributing to population differentiation which can occur in continuous or isolated populations connected by various amounts of gene flow. The willow warbler (Phylloscopus trochilus) is one of the most common songbirds in Fennoscandia. It has a continuous breeding distribution where it is found in all forested habitats from sea level to the tree line and t
Customers and the stakeholders are putting increased pressure on the companies to take responsibility for environmental issues in their supply chain. This may not be very easy for the companies, especially if the suppliers causing pollution are beyond company's direct business connections. This study tries to understand this phenomenon by means of a case study in the fashion industry. A Swedis
The purpose of this thesis is to identify the whole positioning process by means of existing positioning theories as well as interviews with marketing practitioners and consumers. Furthermore, the authors wish to provide the reader with an overview of the complete positioning process as well as how it is used in practice today in order to better understand how well suited positioning theories are
Syftet med denna examensuppsats är att utreda en rad arbetsrättsliga rättigheter och skyldigheter, som kan uppstå vid distansarbete. De områden jag har valt att fokusera på är arbetsbristuppsägningar och turordning, arbetsledningsrätt, arbetsskyldighet och arbetstid samt arbetsmiljö. Två utgångspunkter för arbetet har varit distansarbetsutredningen, SOU 1998:115, och distansarbetsavtalet, som trädMy thesis aims to assess different problems in employment law when dealing with teleworkers. I have chosen to focus on redundancy dismissals and seniority right, the managerial prerogative, the duty to work, working hours and working environment. Two starting points are the Government Inquiry Report on telework, SOU 1998:115, and the telework agreement, which entered into force in July 2002 betwee
