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Överlevnadsanalys med konkurrerande dödsorsaker

Överlevnadsanalys är en gren av statistiken, där tiden från en startpunkt till dess att en eller flera händelser inträffar studeras. Klassisk överlevnadsanalys behandlar enbart en sluthändelse, medan teorin om konkurrerande risker möjliggör analys av multipla sluthändelser. Denna uppsats ger en teoretisk introduktion till båda metoderna men accentuerar modeller för analys av konkurrerande risker, In the field of statistics known as survival analysis, the time from a starting point to one or several endpoints is analysed. Traditional survival analysis deals with one endpoint, while competing risks theory addresses the situation with multiple endpoints. This thesis gives a theoretical introduction to both methods, emphasising the competing risks setting, which is of great importance in many

Cohabitants’ Experiences of Daily Activities and Expectations on How the Housing Adaptation Will Affect Their Own and Their Partners’ Daily Activities

The aim of this qualitative research was to describe the cohabitant’s experience of their daily activities and how they expect that housing adaptation (HA) will affect their own and their partners’ daily activ-ities. Cohabitant means a person who lives in the same residence as the client, with or without giving care to the client. The study included interviewing four cohabitants, all men and aged

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This paper is based upon the observation that in the literature of the past century there are various girl characters who breaks the image of a girl as weak and fragile. The hypothesis of this investigation is that there exist a stereotype of girl character who is rebellious in different types of works published in the twentieth century that have political connotative meaning. The books that are u

Environmental and social responsibility in supply chains: the practice of choice and/or inter-organisational management

The general concern for the state of the environment sets requirements on strategies developed by companies to curb environmental and social impacts of their activities. One of the most notable changes in the way companies work with sustainability issues is the shift of the focus from own operations to improving the performance of supply chains. This paper aims to analyse the practise of corporate

New records of Manota Williston (Diptera: Mycetophilidae) in Europe and North America, including a redescription of Manota unifurcata Lundström and pointers towards the interrelationships among Palaearctic species

Knowledge of the morphology of Manota unifurcata LUNDSTRÖM, 1913 is deepened by a detailed description and illustration of the male genitalia. Based on a study of the characters of the male genitalia in specimens from various countries, it is reconfirmed that M. unifurcata is the only species of Manota WILLISTON in Europe. Its geographic distribution is reviewed, and is augmented by new records fr

Northern magnetic displacements trigger endogenous fuelling responses in a naive bird migrant

In a previous study, we found that juvenile northern wheatears (Oenanthe oenanthe) exposed to a magnetic displacement to the west of their natural migration route increased their body mass. The total intensity and inclination used for the western displacement may also have been interpreted as northern compared to the experimental site (stronger total field intensity and steeper inclination angle).

A BRCA2 mutation incorrectly mapped in the original BRCA2 reference sequence, is a common West Danish founder mutation disrupting mRNA splicing

Inherited mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose carriers to breast and ovarian cancer. The authors have identified a mutation in BRCA2, 7845+1G > A (c.7617+1G > A), not previously regarded as deleterious because of incorrect mapping of the splice junction in the originally published genomic reference sequence. This reference sequence is generally used in many laborator

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver.

LKB1 is a master kinase that regulates metabolism and growth through adenosine monophosphate-activated protein kinase (AMPK) and 12 other closely related kinases. Liver-specific ablation of LKB1 causes increased glucose production in hepatocytes in vitro and hyperglycaemia in fasting mice in vivo. Here we report that the salt-inducible kinases (SIK1, 2 and 3), members of the AMPK-related kinase fa

Making Sense of Extended Producer Responsibility: Towards a framework for policy transfer

Policy transfer of complex interventions often falls into the trap of uninformed, incomplete, and/or inappropriate transfer because the interventions are insufficiently identified with some of their perceived core components. This is no exception in the interspatial learning about extended producer responsibility (EPR) programmes. This thesis aims to transcend this shorthand approach to policy tra

Eutrophication and contaminants in aquatic ecosystems

Eutrophication and persistent pollutants are two of the main environmental problems in European marine and freshwater ecosystems. As they tend to co-occur, interactive processes between eutrophication and contaminants are suggested, that may lead to environmental effects that cannot be predicted from each process alone. In order to predict the consequences of remedial measures (changing the input

Digital reglering av klimatprocesser

Behovet av klimatreglering har ökat kraftigt sedan 1960-talet. Ett av skälen till detta är den ändrade byggtekníken, som innebär lättare konstruktioner med större inre värmebelastning från belysning, maskiner, personer och solinstrålning genom stora fönsterytor. De ökade värmebelastningarna kan klaras av med ett flertal olika klimatsystem. Dessa system kräver någon form av reglering. Under 1970-ta

Serum metabolite signature predicts the acute onset of diabetes in spontaneously diabetic congenic BB rats

The clinical presentation of type 1 diabetes is preceded by a prodrome of beta cell autoimmunity. We probed the short period of subtle metabolic abnormalities, which precede the acute onset of diabetes in the spontaneously diabetic BB rat, by analyzing the serum metabolite profile detected with combined gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS