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Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. We replicated 26 signals and identified 10 new lead associations from previously reported loci. Rare-variant associations tended to be specific to po

Lamenting Karbala in Europe : Husayni Liturgy and Discourses of Dissent amongst Diasporic Bahraini and Lebanese Shiis

The presence of Shii communities in Europe is increasingly felt, especially as they establish independent religious and social infrastructures. Supporters of different Shii–Islamist political parties have established transnational links connecting diasporic communities with their countries of origin. These links have shaped and been shaped by religious, political and social dynamics in the Middle

Hearing loss after bacterial meningitis, a retrospective study

Background: Hearing loss is a common sequela after bacterial meningitis, but risk factors for this are poorly studied, particularly in relation to concurrent acute otitis media (AOM). Aims: The aim of this study was to investigate incidence and risk factors for hearing loss in patients treated for bacterial meningitis. Methods: In this retrospective study, medical records for patients admitted to

Societal changes and new conditions for the management of large construction projects

The construction industry is often described as mature, conservative and resistant to change in research studies, governmental reports as well as in media. Both scholars and policy makers thereby find it critical to encourage innovation, development, and change within the construction industry. This study takes on a different perspective by investigating changes that have actually taken place. The

Phenotypic plasticity is aligned with phenological adaptation on both micro- and macroevolutionary timescales

In seasonally variable environments, phenotypic plasticity in phenology may be critical for adaptation to fluctuating environmental conditions. Using an 18-generation longitudinal dataset from natural damselfly populations, we show that phenology has strongly advanced. Individual fitness data suggest this is likely an adaptive response towards a temperature-dependent optimum. A laboratory experime

Association between serum urate and CSF markers of Alzheimer's disease pathology in a population-based sample of 70-year-olds

Introduction: The relationship between urate and biomarkers for Alzheimer's disease (AD) pathophysiology has not been investigated. Methods: We examined whether serum concentration of urate was associated with cerebrospinal fluid biomarkers, amyloid beta (Aβ)42, Aβ40, phosphorylated tau (p-tau), total tau (t-tau), neurofilament light (NfL), and Aβ42/Aβ40 ratio, in cognitively unimpaired 70-year-ol

‘Distance creates distance’ : preschool staff experiences and reflections concerning preschool introduction during the covid-19-Pandemic

The social restrictions during the covid-19 pandemic have challenged many aspects of preschool everyday life. Particularly vulnerable to these restrictions is the aspect of introducing new children to preschool, since preschool introduction constitutes a natural arena for establishment of preschool staff’s relationships with children and their parents. Based on analysis of open-ended survey data (

Serum immunoglobulin concentrations and risk of type 2 diabetes mellitus in adults : a prospective cohort study from the TCLSIH study

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion and/or insulin action. Increasing evidence suggests that inflammation played an important role in the pathogenesis of T2DM. Prospective studies on the link between immunoglobulins concentrations and the risk of T2DM in adults are limited. We developed a cohort study in

European Obspack compilation of atmospheric carbon dioxide data from ICOS and non-ICOS European stations for the period 1972-2023; : obspack_co2_466_GLOBALVIEWplus_v8.0_2023-04-26

This data package contains high accuracy CO2 dry air mole fractions from 58 ICOS and non-ICOS European observatories at in total 132 observation levels, collected by the ICOS Atmosphere Thematic Centre (ATC) and provided by the station contributors. The package is part of the Globalviewplus v8.0 data product, released in 2022 and is intended for use in carbon cycle inverse modeling, model evaluati

Widespread Pesticide Distribution in the European Atmosphere Questions their Degradability in Air

Risk assessment of pesticide impacts on remote ecosystems makes use of model-estimated degradation in air. Recent studies suggest these degradation rates to be overestimated, questioning current pesticide regulation. Here, we investigated the concentrations of 76 pesticides in Europe at 29 rural, coastal, mountain, and polar sites during the agricultural application season. Overall, 58 pesticides

Rural gentrification and heritage-led resistance: walking through a manifestation of nostalgia or an active social response?

Rural gentrification, amenity-led in-migration and displacement in more attractive parts of the countryside are taking up more of the rural discourse. Along this, the centrality of landscape, as a driver for gentrification and as something affected by the same notion, is establishing. This paper explores the paradox of how people move to a certain area because they find that particular landscape a

Towards the development of legislative framework for solar neighborhoods

The growing implementation of sustainable urban infrastructure, utilizing solar energy for heat and power generation, daylighting, and thermal comfort, has intensified the focus on sustainability standards and guidelines. Nevertheless, a noticeable deficiency persists in regulations that specifically address solar energy access and protection, posing a barrier to the diffusion of solar-centric nei

Will the Center Hold? What Research Centers Do to Universities and to Societal Challenges

Research centers represent a specific organizational format for linking the traditional university organization with external actors, goals, and processes in time-limited, concentrated efforts of research and collaboration. Yet, the center format contains large variations, and centers act as interfaces between university organizations, societal actors, and research funders in multifaceted ways. In