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The molecular specification of neural precursor cells has been suggested to be a progressive process, with a transition from an early requirement for extrinsic signals to intrinsic mechanisms. Thus, the cells in the nervous system acquire distinct fates in response to extrinsic signals, which activate repertoires of transcription factors in a region and cell type specific manner. The studies in th
An increasing number of market- and technology-driven software development companies face the challenge of managing several thousands of requirements written in natural language. The large number of requirements causes bottlenecks in the requirements management process and calls for increased efficiency in requirements engineering. This thesis presents results from empirical investigations of usi
Modeling and simulation are established techniques for solving design problems in a wide range of engineering disciplines today. Dedicated computer languages, such as Modelica, and efficient software tools are available. In this thesis, an extension of Modelica, Optimica, targeted at dynamic optimization of Modelica models is proposed. In order to demonstrate the Optimica extension, supporting sof
Empirical studies focusing on the subjective experience of health among patients in contact with the mental health services are rare and most questionnaires are based on a medical model that emphasizes objectively observed disease-oriented health indicators. In studies I and II perceptions of the concept of health among patients and nurses in mental health services were explored and described usin
The main theme of the thesis is an analysis of three texts by the Czech author Bohumil Hrabal (1914 – 1997), namely ’Mrtvomat’ (’Mrtvomat’, 1949), This City is in the Joint Care of Its Inhabitants (Toto mìsto je ve spoleèné péèi obyvatel, 1967), and ’Legend Played on Strings Stretched Between the Cradle and the Coffin’ (’Legenda zahraná na strunách mezi kolébkou a rakví’, 1968). These texts are co
Sleep disordered breathing (SDB) including obstructive and central sleep apnoea/ hypopnoea as well as periodic breathing (PB) is common and is believed to increase risk for mortality in patients with congestive heart failure (CHF). Mandibular advancement device (MAD) has widely been recommended for treatment of obstructive sleep apnoea but the method has never been investigated for treatment of SD
The thesis has provided with systematic information about how people with schizophrenia live their everyday life, and the results have shown significant relationships between occupational perspectives and health. The thesis departed in two in-depth studies that concerned time use and occupational engagement in relation to what people with schizophrenia do in their everyday life, with whom they are
The overall aim of this study has been to come to a better understanding of what it means to be a Montessori teacher, by getting a group of Montessori teachers to reflect on their lives and work. Data exploration has comprised journals, interviews, written reflections and collaborative contextual analysis. Analysis of the teachers' occupational life histories and the findings as a whole have been
Patients who are incompetent need a surrogate decision maker to make treatment decisons on their behalf. One of the main ethical questions that arise in this context is what standard ought to govern such decision making. According to the Substituted Judgment Standard (SJS), a surrogate ought to make the decision that the patient would have made, had he or she been competent. Although this standard
Den icke-fiktiva svenska naturskildringen har så gott som uteslutande förknippats med manliga namn. I den här undersökande essän vill jag vidga fältet genom att presentera ett antal kvinnliga skribenter och deras olika förhållande till naturen: Esther och Ruth Kolthoff, Karin Jansson, Elsa af Trolle, Harriet Hjorth, Margit Geijer, Margaret von Bismarck, Margareta Ekström, Ingegerd Möller.
This thesis proposes the use of two concepts: accessibility and chemical activity. Accessibility describes the mass quantity of PAHs that is or can become available within a given time span and under given conditions. Chemical activity quantifies the energetic state of the PAHs that determines the potential for spontaneous physicochemical processes, such as diffusion and partitioning. Chemical act
Peptostreptococcus magnus and group C/G streptococci are Gram-positive cocci that are part of the normal flora and reside in more or less the same locations in the host. Protein G of group C/G streptococci was originally described as binding IgGFc of several species and later shown to also bind human serum albumin and albumins from various animal species. From albumin-binding strains of P. magnus
The industrial production of preserves includes several unit operations which all affects sensorial properties as well as the nutritional value of the final product. Thawing is a crucial unit operation, since then both chemical and physical changes take place. Thawing strawberries in selected aqueous media could gave both firmer strawberries and smaller weight loss than if air was used as the tha
This thesis investigates the relationship between the “New Negro” moment of the early twentieth-century America and the Old World of Europe, as represented in James Weldon Johnson’s The Autobiography of an Ex-Colored Man (1912), Jessie Fauset’s There is Confusion (1924), and Nella Larsen’s Quicksand (1928). In the nineteenth century, Europe functioned as a symbol of freedom, education and art in t
In this thesis the notion of place is studied by way of investigating the “non-place” which is excluded or opposed, whenever a place is defined. “Non-place” is used here as a meta-concept, covering various recurring types of opposition to “place,” and it therefore represents a profoundly incoherent spect-rum of realities and concepts. Hence, a “non-place” may in this investigation appear as “lefto
Each immunoglobulin (Ig) V gene segment contains an upstream promoter region. The octamer element and the TATA box are the only elements that are conserved in all Ig promoters. The presence of the octamer element is necessary, but not sufficient to support high levels of transcription. Therefore, the activity of other co-stimulatory elements is required. This investigation has focused on the study
The sound absorption characteristics of resonant absorbers, implemented as perforated suspended inner ceilings attached with thin porous layers, are investigated. Several existing theories model the principal absorption mechanisms, but the interaction with the outer sound field influences the absorption in ways that can be modelled with new approaches. The effect of arranging the absorbing surfac
