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Spatial Temperature Differences in Portal Frame Bridges

Thermal actions are considered in the design of bridges, as temperature variations can lead to restraint stresses and subsequent cracking. However, load descriptions are in some cases oversimplified or incompatible with modern applications, and background studies are limited. This paper therefore aims to develop a more detailed load description for the load case describing temperature differences

Can we fly less? Evaluating the ‘necessity’ of air travel

Air travel is often justified as ‘necessary’ or ‘unavoidable’, in the sense that trips have purpose and value. Yet it is evident that people travel for reasons that may include forced and voluntary movement, with motives ranging from visiting friends and family, to leisure, or business. In light of the challenge to decarbonise transport, and the need to reduce greenhouse gas emissions, this paper

Incretin-based medications (GLP-1 receptor agonists, DPP-4 inhibitors) as a means to avoid hypoglycaemic episodes

Hypoglycaemia is common in both type 1 and type 2 diabetes and has both acute and long-term consequences. Therefore, a key to proper glucose-lowering therapy in diabetes is to avoid or prevent hypoglycaemia. Incretin therapy (DPP-4 inhibitors and GLP-1 receptor agonists) offers an advantage in this respect, because it reduces glucose with a low risk of hypoglycaemia, both in monotherapy and in com

Presence in affective heritagescapes: Connecting theory to practice

A recent shift in tourism studies has focused on the emotional, affective, embodied, and performative dimensions of heritage landscape experience. However, such research often struggles to transform theoretical and conceptual discussions into practical and applicable terms that can be effectively implemented by site managers. The concept of presence is therefore proposed to identify emotional and

Dimethylguanidino Valerate : A Lifestyle-Related Metabolite Associated With Future Coronary Artery Disease and Cardiovascular Mortality

Background Identification of lifestyle modifiable metabolic pathways related to cardiometabolic disease risk is essential for improvement of primary prevention in susceptible individuals. It was recently shown that plasma dimethylguanidino valerate (DMGV) levels are associated with incident type 2 diabetes mellitus. Our aims were to investigate whether plasma DMGV is related to risk of future coro

Pregnancy Complication History in 10-Year Cardiovascular Disease Risk Prediction: a Review of Recent Evidence

Purpose of ReviewWomen with prevalent pregnancy complications (including preterm birth and preeclampsia) have twice the risk of later cardiovascular disease (CVD) compared to unaffected women. Current prevention guidelines recommend that reproductive history should be part of a woman’s CVD risk assessment. This review synthesizes recent findings on the value of history of pregnancy complications i

Smart Public Transport in Rural Areas: Prospects, Challenges and Policy Needs

There is a heavy dependence on cars for people living in rural areas and small towns. The countryside has so far been left out of the transition to carbon-free transport, and public transport shares are low in rural areas. New information and communication technology (ICT) solutions and autonomous vehicles (AVs) have the potential to improve the conditions for public transport in rural areas, as t