Filtyp
PTEN is an important tumor suppressor gene that antagonizes the oncogenic PI3K/AKT signaling pathway and has functions in the nucleus for maintaining genome integrity. Although PTEN inactivation by mutation is infrequent in breast cancer, transcript and protein levels are deficient in >25 % of cases. The E3 ubiquitin ligase NEDD4 (also known as NEDD4-1) has been reported to negatively regulate PTE
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple n
Today, with many of the technological issues of integrated information management resolved (perhaps excluding the matter of interoperability), defining the content and status of BIM information deliveries remains both a practical and a theoretical problem. New BIM tools and new design processes and procedures have led to a certain confusion of what information is needed for particular BIM uses. Th
The Late Ordovician-Early Silurian succession in Jamtland includes the marine Kogsta Siltstone, which is unconformably overlain by the shallow-water Ede Quartzite that grades into the open-marine Berge Limestone. A Hirnantia shelly fauna dates the uppermost Kogsta Siltstone as Hirnantian, and shelly fossils indicate an Aeronian age for the Berge Limestone. Biostratigraphically highly diagnostic co
