Sökresultat

Individuals with rapidly progressing atherosclerotic plaques are at higher risk of experiencing acute complications. Currently, we lack knowledge regarding factors in human plaque that cause rapid progression. Using the 14C bomb-pulse dating method, we assessed the physical age of atherosclerotic plaques and which biological processes were associated with rapidly progressing plaques. Interestingly

Superantigens (SAgs) are bacterial enterotoxins produced by Staphylococcus aureus. Staphylococcal enterotoxin type A (SEA), a staphylococcal superantigen, has been shown to bind to the cytokine signalling receptor glycoprotein 130 (gp130). The structural details, as well as the exact physiological role of this interaction, remain unclear. Here, we describe the structural details of the SEA–gp130 c

Autoantigen discovery is a critical challenge for the understanding and diagnosis of autoimmune diseases. While autoantibody markers in current clinical use have been identified through studies focused on individual disorders, we postulated that a reverse approach starting with a putative autoantigen to explore multiple disorders might hold promise. We here targeted the epidermal protein transglut

För att se om antalet D-interaktioner kunde minskas skickades information om interaktioner på individnivå till vårdcentraler.Allmänläkarna ombads att utifrån medföljande rekommendationer ompröva behandlingen och besvara en enkät.Mindre än hälften av D-interaktionerna berodde på medvetna ordinationsval.Mer än hälften av interaktionerna hade uppkommit det senaste året, trots tydlig varning vid ordin

The aim of the present paper is to explore the interrelated and complex relationships between religionsvetenskap (Religious Studies), religionskunskap (Religious Education) and religionsdidaktik (Religion and Education). After briefly outlining the concurrent developments of Religious Studies as a university discipline and Religion and Eudcation as a non-confessional school subject, both of which

Differences by sex in lung cancer incidence and mortality have been reported which cannot be fully explained by sex differences in smoking behavior, implying existence of genetic and molecular basis for sex disparity in lung cancer development. However, the information about sex dimorphism in lung cancer risk is quite limited despite the great success in lung cancer association studies. By adoptin

AMP-activated protein kinase (AMPK) activation is considered a useful strategy for the treatment of type 2 diabetes (T2D). It is unclear whether the expression and/or activity of AMPK in adipocytes is dysregulated in obesity. Also, the expression/activity pattern of AMPKβ isoforms, which are targets for AMPK activators, in adipocytes remains elusive. In this study we show that the two AMPKβ isofor

This study investigates patterns of seasonal variation in hours worked by women employed in home-based industrial production in Sweden in the early 20th century. Previous studies often describe workers in this type of production as the most flexible segment of industrial workers, and highly dependent on seasonal fluctuations in supply and demand. However, few have studied this empirically. This st

Residential energy consumption is a consequence of household members’ activities in their homes. Analysing and understanding energy consumption in households therefore needs to start from household activities and everyday life. From household members’ time diaries, we can analyse and learn about when, where and what energy-related activities occur in the household, involving what household members

Building Information Modelling (BIM) objects represent building products in design, simulation, and procurement processes. This paper explores how BIM objects could be created and exchanged to enable the diffusion of innovative products with enhanced sustainability performance. Two BIM library platforms were examined by taking a new approach that integrates the concepts of sustainable value, diffu

Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally

The right of access to court and the right to a fair trial are fundamental rights guaranteed in all democratic states. The basic ideas are that anyone is entitled to have a dispute heard by a court of law in a procedure that meets certain requirements, i.e., a fair trial, and that the State has a duty to make such judicial dispute-resolution procedures possible. One of the most fundamental legal p

This squib is a brief state of the art overview of declarative V1 in Icelandic, old and modern. Three(relevant) types of such clauses are discussed: Narrative Inversion, with an overt topical subjectdirectly after the verb, Presentational V1, with an overt non-topical subject, and Null-subject V1.Narrative Inversion is a robust main clause phenomenon, whereas Presentational V1 and Null-subjectV1 a

The latest edition of the Swiss standard SIA181(2006) Protection against noise in Buildings [1], introduces a new methodology regarding the tests to be performed in new constructions for noise induced by human using service equipment in bathroom and kitchen. In this method, a specific pendling hammer has been developed especially for evaluating the decoupling efficiency of service equipment. The g

EU policy documents on the effects of the global migration wave suggest that culture has an important role in promoting inclusion as well as developing and maintaining democracy. These expectations on culture places music education as a potential key factor in coping with the effects of the current refugee situation. In this paper, it is argued that European music educational systems are given a t

This interview is part of a major research project that is based on interviews and discussions with influential decision-makers, facilitators, mediators and negotiators who were involved in Arab-Israeli peace negotiations over the past three decades, as well as on archival research in Oslo, London, Washington and Jerusalem. Semi-structured in-depth interviews were conducted with more than 80 Israe

While previous research has advocated the use of online sales channels as a driver for international expansion, the nature of the relationship between e-commerce and international sales is still unexplored. The purpose of this paper is to create a parsimonious model where we investigate whether, and to what extent, strategies pertaining to the geographical scope of international operations moderat