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Pancreatic beta-cell loss represents a key factor in the pathogenesis of diabetes. Since the influence of purinergic signaling in beta-cell apoptosis has not been much investigated, we examined the role of the ADP receptor P2Y(13) using the pancreatic insulinoma-cell line MIN6c4 as a model system. Real time-PCR revealed high expression of the ADP receptors P2Y(1) and P2Y(13). Adding the ADP analog
We analyze empirically product-price variation across export destinations using detailed firm-product data. Most recent studies using highly disaggregated data emphasize variations in product quality as an explanation as to why firms charge different prices for the same product on different export markets. In this paper, we take an alternative approach and assume that variations in firms' export p
Most organizational findings on Triple Helix modes of interaction have originated in studies of high-tech sectors and emergent industries, whereas low-tech sectors and mature industries to a less extent have been explored in the Triple Helix literature. A foresight initiative aiming at an enhanced renewal of the mature food industry in the region of Skane, was conducted 2006-2007. Findings from th
Background and purpose Can an increased focus on values in working life be a factor in stress prevention? Values are defined as the shared principles which guide behaviour in an organisation. The purpose of this study was to describe how patients with musculoskeletal pain perceive the importance of values in relation to coping with daily stress and in relation to health. Methods Patients receivi
The new estimates of the Maddison Project show that the p.p.p. GDP per capita ratio between Bolivia and Finland has changed from 0.68 ca. 1850 to 0.16 in 2015; similarly, that between Chile and Norway from 0.65 to 0.28. The aim of this article is to present a review of the literature and available quantitative evidence to understand how these extreme differences became possible between countries w
This paper examines the short-term effect between take-up of Social Assistance Benefit (SAB) and mental health. Using a panel dataset including rich yearly register data on e.g. income, income sources, unemployment and types of pharmaceutical consumption for over 140,000 Swedes 2006-2012, we quantify the importance of the psychosocial dimensions (e.g. shame and guilt) of the socioeconomic status –
There is a great need for targeted protein assays with the capacity of sensitive measurements in complex samples such as plasma or serum, not the least for clinical purposes. Proteomics keeps generating hundreds of biomarker candidates that need to be transferred towards true clinical application through targeted verification studies and towards clinically applicable analysis formats. The immunoaf
A number of papers have provided insight into frequencies of violence-related trauma, especially skull trauma, in Northern European skeletal assemblages dating to the Neolithic and Bronze Age. Although the cases are often well described, they lack further discussion about the consequences of skull trauma for the injured individual and the implications for the surrounding society, especially consid
The new estimates of the Maddison Project show that GDP per capita ratio at purchasing power parity (ppp) between Bolivia and Finland has changed from 0.68 ca. 1850 to 0.16 in 2015; similarly, that between Chile and Norway from 0.65 to 0.28. The aim of this article is to present a review of the literature and available quantitative evidence to understand how these extreme differences became possib
There is a well-documented large positive correlation between education and health and yet it remains unclear as to whether this is a causal relationship. Potential reasons for this lack of clarity include estimation using different methods, analysis of different populations and school reforms that are different in design. In this paper we assess whether the type of school reform, the instrument a
Glucose-stimulated insulin secretion is biphasic, with a rapid first phase and a slowly developing sustained second phase; both are disturbed in type 2 diabetes (T2D). Biphasic secretion results from vastly different release probabilities of individual insulin granules, but the morphological and molecular basis for this is unclear. Here, we show that human insulin secretion and exocytosis critical
The impact of different passive protective measures against external vertical fire spread was investigated using the numerical tool Fire Dynamics Simulator (FDS). The numerical study was divided into a validation study and a comparative analysis. The validation study was performed to evaluate FDS as a calculation tool for modelling external vertical fire spread and was conducted using experimental
Under istider, när stora mängder havsvatten var bundet i inlandsisar, var den globala havsnivån lägre än idag och stora delar av kontinentalsockeln torrlagd. Den senaste istiden (cirka 115 000–12 000 år sedan) var inget undantag, då torrlagda områden utvecklades till ekologiskt rika kustområden som möjliggjorde människans spridning över världen. När inlandsisarna smältesteg havsnivån och dessa lanDuring times of lower global sea level, vast areas of the coastal shelf were exposed and converted into ecologically diverse coastal landscapes that wereattractive for human occupation. The landscapes were subsequently flooded during the deglaciation, but well-preserved remains of these landscapes andtheir inhabitants can today be found on the seafloor. In the southern Baltic Basin, where the comp
