Sökresultat

Recently, acqui-hiring, which refers to the acquisitions driven by gaining access to target human capital, has emerged as a proliferating phenomenon in acquisitions of small technology firms. However, we still know little about this phenomenon, particularly outside the community of Silicon Valley. This study sheds new light on the nature of acqui-hiring by focusing on what drives acqui-hiring. Usi

Protein homeostasis depends on many fundamental processes including mRNA synthesis, translation, post-translational modifications, and proteolysis. In the late 70s and early 80s the discovery that the small 76 amino acid protein ubiquitin could be attached to target proteins via a multi-stage process involving ubiquitin-activating enzymes, ubiquitin conjugating enzymes, and ubiquitin ligases, reve

Venomous animals have evolved diverse molecular mechanisms to incapacitate prey and defend against predators. Most venom components disrupt nervous, locomotor, and cardiovascular systems or cause tissue damage. The discovery that certain fish-hunting cone snails use weaponized insulins to induce hypoglycemic shock in prey highlights a unique example of toxins targeting glucose homeostasis. Here, w

The association between higher education and political attitudes is well-recognized, and research suggests that socialization amongst peers is one of the most probable mechanisms explaining a possible attitudinal change. However, identifying a socialization effect is difficult due to self-selection mechanisms and limitations in data availability. This article empirically investigates the underlyin

This article focuses on explaining management control under post-new public management (NPM). Drawing on the lessons from a case study, the article aims to advance the discussion of what post-NPM, as a new governance innovation, is and what problems practitioners encounter when they try to engage in post-NPM–oriented governance. The study reports the transformation of both management and control a

The entitlement to access assistive technology (AT) is fundamental for all individuals. However, challenges encountered during societal crises can significantly impact opportunities for participation and engagement among AT users. Understanding the implications of crises and disasters on AT provision along with their repercussions for end users is crucial. This research endeavors to investigate thThe entitlement to access assistive technology (AT) is fundamental for all individuals. However, challenges encountered during societal crises can significantly impact opportunities for participation and engagement among AT users. Understanding the implications of crises and disasters on AT provision along with their repercussions for end users is crucial. This research endeavors to investigate th

Background: Summary statistics often hide individual patients' suffering, thereby impeding quality improvement efforts. Objectives: We aimed to show the experience of a population with health care toward the end of life while preserving the experience of the individual. Design: We developed a data display method called per-patient illness trajectory analysis. We tested it using a demonstration coh

Gymnasie- och universitetsutbildning var länge en elitens domän. Med ekonomisk tillväxt och ökande teknisk komplexitet växte dock behovet av specialiserad kunskap och färdigheter. Inför och under industrialiseringen tog systemen för högre utbildning emot ett ökande antal studenter och breddades med ett växande utbud av kurser och typer av utbildningsinstitutioner.Danmark, Norge och Sverige utgör rHigh school and university-level education was long an elite pursuit. However, with economic growth and rising technical complexity, the need for specialised knowledge and skills increased. In the run-up to and during industrialisation, higher education systems admitted a growing number of students and diversified across an increasing range of courses and types of educational institutions.Denmark,

This chapter presents the long-term clinical outcomes and prognosis of COVID-19. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a global pandemic infecting over 773 million people and causing over seven million deaths worldwide as of December 2023 (WHO Coronavirus). Despite the United Nations proclaimed the coronavirus disease 19 (COVID-19) pandemic officially over on M

Endoplasmic reticulum (ER) membrane resident P5A-ATPases broadly affect protein biogenesis and quality control, and yet their molecular function remains debated. Here, we report cryo-EM structures of a P5A-ATPase, CtSpf1, covering multiple transport intermediates of the E1 → E1-ATP → E1P-ADP → E1P → E2P → E2.Pi → E2 → E1 cycle. In the E2P and E2.Pi states a cleft spans the entire membrane, holding

Outcome under-ascertainment, characterized by the incomplete identification or reporting of cases, poses a substantial challenge in epidemiologic research. While capture-recapture methods can estimate unknown case numbers, their role in estimating exposure effects in observational studies is not well established. This paper presents an ascertainment probability weighting framework that integrates