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The western fertility decline is arguably the most significant demographic change to have occurred in the past 200 years, yet its causes and processes are still shrouded in ambiguity due to a lack of individual-level longitudinal data. A growing body of research has helped improve our understanding of the decline's causes by examining the development of socioeconomic differences in fertility using

Competing Institutional Logics in Diaconal Work “Institutional logics” is a concept within the context of institutional theory. Institutions can be defined as patterns of activity rooted in material practices and symbolic systems. These institutional orders are all shaped by the history and each of them has a central logic that guides its organizing principles. The institutional logic provides

Ca2+-sensor proteins are generally implicated in insulin release through SNARE interactions. Here, secretagogin, whose expression in human pancreatic islets correlates with their insulin content and the incidence of type 2 diabetes, is shown to orchestrate an unexpectedly distinct mechanism. Single-cell RNA-seq reveals retained expression of the TRP family members in β-cells from diabetic donors.

The challenge of multi-use forestry is to fulfil a range of economic, ecologic and social goals in a sustainable way, accounting for synergies and trade-offs among the ecosystem services provided. Climate changes add to the complexity via effects on forest ecosystem processes, such as primary production and respiration, and also by adding a new goal on the agenda: the role of forests in climate mi

The localization of glucokinase in pancreatic beta-cell nuclei is a controversial issue. Although previous reports suggest such a localization, the mechanism for its import has so far not been identified. Using immunofluorescence, subcellular fractionation and mass spectrometry, we present evidence in support of glucokinase localization in beta-cell nuclei of human and mouse pancreatic sections, a

Objective: The aim of this study was to evaluate the association of self-assessed preoperative physical activity, alcohol consumption and smoking with self-assessed quality of life, negative intrusive thoughts and depressed mood after radical prostatectomy. Materials and methods: The Laparoscopic Prostatectomy Robot Open (LAPPRO) trial was a prospective, controlled, non-randomized longitudinal tri

The paper investigates possible effects of cross-linguistic variation on measures of syntactic complexity in 60 texts from learners of L2 English, L3 French and L4 Italian at CEFR level A and CEFR level B. A previous study by Gyllstad et al. (2014) showed significant differences between proficiency levels for two length measures of complexity in English and French, but not in Italian. In this pape

The driving force behind the current global type 2 diabetes epidemic is insulin resistance in overweight and obese individuals. Dietary factors, physical inactivity, and sedentary behaviors are the major modifiable risk factors for obesity. Nevertheless, many overweight/obese people do not develop diabetes and lifestyle interventions focused on weight loss and diabetes prevention are often ineffec

Finding new causes of monogenic diabetes helps understand glycaemic regulation in humans. To find novel genetic causes of maturity-onset diabetes of the young (MODY), we sequenced MODY cases with unknown aetiology and compared variant frequencies to large public databases. From 36 European patients, we identify two probands with novel RFX6 heterozygous nonsense variants. RFX6 protein truncating va

Aims To identify areas in need of quality improvement by investigating inpatients' perceptions of quality of care, and to identify differences in perceptions of care related to patient gender, age and type of admission. Background Nursing managers play an important role in the development of high-quality care. Methods Quality of care was assessed using the Quality from the Patients' Perspective (Q

This research examines the practices of consumers that are made possible by a 'low-end' street, and how these shopping practices in turn shape and maintain a high street at the urban margins. It locates itself within the academic inquiries of cultural geographies of retail.Södergatan is the field of the study, the main shopping street in the stigmatized southern part of city of Helsingborg in Swed

We are seeing today an increased interest in ethics, the environment, and social responsibility at the same time as the individual is expected, in different ways, to realize him-/herself through consumption. These interests coincide with the establishment of ethical markets for re-use and second-hand. In this paper we investigate and map out the ethical shopping spaces in Helsingborg, and how thes

An increasing demand for energy-efficient buildings has led to an increasing focus on predicted energy performance once a building is in use. Many studies have identified a performance gap between predicted energy use and actual measured energy use once buildings are in the user phase. However, none of the identified studies normalise measured energy use for both internal and external deviating bo

To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLADRB5 (odds ratio (