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Genetic variation plays ail important role in osteoporosis and a prime candidate gene is Collagen alpha2(I) (COL1A2). A coding polymorphism (rs42524) in COL1A2 has previously been associated with intracranial aneurysms. Here the effects of this polymorphism have been Studied in relation to bone mineral density (BMD) and prevalences of stroke and myocardial infarction (MI). rs42524 was genotyped in
The general concern for the state of the environment sets requirements on strategies developed by companies to curb environmental and social impacts of their activities. One of the most notable changes in the way companies work with sustainability issues is the shift of the focus from own operations to improving the performance of supply chains. This paper aims to analyse the practise of corporate
The focus on this thesis is the factorial survey approach as a method for studying professional judgements in social work. The factorial survey approach, which was first introduced in the social sciences around the beginning of the 1980s, constitutes an advanced method for measuring human judgements of social objects. At the general level, this quasi-experimental approach involves presenting respo
Policy transfer of complex interventions often falls into the trap of uninformed, incomplete, and/or inappropriate transfer because the interventions are insufficiently identified with some of their perceived core components. This is no exception in the interspatial learning about extended producer responsibility (EPR) programmes. This thesis aims to transcend this shorthand approach to policy tra
Biological invasions often cause major perturbations in the environment and are well studied among macroorganisms. Less is known about invasion by free-living microbes. Gonyostomum semen (Raphidophyceae) is a freshwater phytoplankton species that has increased in abundance in Northern Europe since the 1980's and has expanded its habitat range. In this study, we aimed to determine the genetic popul
LKB1 is a master kinase that regulates metabolism and growth through adenosine monophosphate-activated protein kinase (AMPK) and 12 other closely related kinases. Liver-specific ablation of LKB1 causes increased glucose production in hepatocytes in vitro and hyperglycaemia in fasting mice in vivo. Here we report that the salt-inducible kinases (SIK1, 2 and 3), members of the AMPK-related kinase fa
Eutrophication and persistent pollutants are two of the main environmental problems in European marine and freshwater ecosystems. As they tend to co-occur, interactive processes between eutrophication and contaminants are suggested, that may lead to environmental effects that cannot be predicted from each process alone. In order to predict the consequences of remedial measures (changing the input
