The peroxisome proliferator-activated receptors (PPARs) are transcription factors belonging to the nuclear receptor superfamily. Several reports have shown that PPARdelta is involved in lipid metabolism, increasing fat oxidation and depleting lipid accumulation. Whether PPARdelta is involved in the regulation of glucose metabolism is not completely understood. In this study, we examined effects of

The Hanseatic League, a late medieval merchant association with roots in northern German towns, is credited with the establishment of extensive economic and geographic connections and considerable impact on the development of urban culture around the Baltic and the North Sea. Its merchants, regularly crossing the Seas and settling in foreign ports, created a network of diasporic communities often

The aim of this article is to show that ideas pertaining to sacred sexuality or sacred marriage are as old as Sumerian culture. While mainstream Christianity developed an alternate view on sexuality, the Jewish Kabbalah transmitted similar ideas. In Asia, sacred sexuality has been an integrated dimension of Hinduism and Buddhism. All these spiritual traditions camte together in 18th century London

In recent years the concept of urban atmosphere seems to appear everywhere – discussed as a marketing strategy, part of an eventscape, a crucial element in place-marketing or a key feature in the production of brandscapes. An attractive city should contain settings with attractive atmosphere or ambiance. This paper discusses what we can learn from this rapid expansion. What happens when the elusiv

Biomass gasification for energy or hydrogen production is a field in continuous evolution, due to the fact that biomass is a renewable and CO2 neutral source. The ability to produce biomass-derived vehicle fuel on a large scale will help to reduce greenhouse gas and pollution, increase the security of European energy supplies, and enhance the use of renewable energy. The Varnamo, Biomass Gassifica

We have recently shown that low plasma levels of mid-regional atrial natriuretic peptide (MR-ANP) predict development of diabetes and glucose progression over time, independently of known risk factors for diabetes development. However, since MR-ANP levels might be influenced by unknown factors causing diabetes, we cannot rule out that such relationship might be confounded. Previous studies have sh

The main claim of this paper is that embedded V2 clauses in Mainland Scandinavian have the same syntactic structure as main clauses. This means that embedded V2 clauses contain a Force head, and as a consequence, embedded declarative V2 clauses will normally be asserted. Embedded V2 clauses are also similar to main clauses in that they contain linkers which encode the local speaker and addressee.

In experimental studies, enkephalins (ENKs) and related opioids have been implicated as negative regulators of breast cancer development by enhancing immune-mediated tumoral defense as well as directly inhibiting cancer cells. We hypothesized that plasma levels of ENKs are predictive of the long-term breast cancer risk. Therefore, our objective was to measure pro-ENK A, a surrogate for mature ENK,

The performance of new firms is important for economic development but research has produced limited knowledge about the key relationships among growth, profitability, and survival for new firms. Based on evolutionary theory, we develop a model about how new firms resolve uncertainty about their ability to prosper in a market by monitoring changes in profitability. Our model predicts selection pre

Online evaluations are one of the most important innovations in tourism in recent years, often combining a review/rating (business-specific evaluation) and a ranking (inter-business comparison). As online reputation determines economic success, tourism managers may be tempted to manipulate online content. This paper presents the results from a qualitative study involving 20 hotel managers in south

Type 2 diabetes (T2D) develops due to insulin resistance and impaired insulin secretion, predominantly in genetically predisposed subjects exposed to nongenetic risk factors like obesity, physical inactivity and ageing. Emerging data suggest that epigenetics also play a key role in the pathogenesis of T2D. Genome-wide studies have identified altered DNA methylation patterns in pancreatic islets, s