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Using a multitissue, genome-wide gene expression approach, we recently identified a gene module linked to the extent of human atherosclerosis. This atherosclerosis module was enriched with inherited risk for coronary and carotid artery disease (CAD) and overlapped with genes in the transendothelial migration of leukocyte (TEML) pathway. Among the atherosclerosis module genes, the transcription cof

The effects of alkylresorcinols (ARs) isolated from rye bran on adipocyte lipolysis, hormone-sensitive lipase activity and phosphorylation and on phosphorylation of protein kinase A substrates were studied. Preincubation with ARs for 18 h suppressed catecholamine-stimulated lipolysis in 3T3-L1 adipocytes. Furthermore, phosphorylation of hormone-sensitive lipase (HSL), a key lipase responsible for

Subendothelial LDL-adhesion and its subsequent oxidation are considered as key events in the development of atherosclerotic lesions. During oxidation of LDL, reactive aldehydes such as malondialdehyde (MDA) are formed, which modify apolipoprotein B100. However, the possibility that these reactive aldehydes could leak out of the LDL-particle and modify surrounding extracellular matrix proteins has

Adipose tissue has an important function in total energy homeostasis and its dysregulation may contribute to life-style related diseases such as type 2 diabetes, cancer and cardiovascular diseases. The aim of this study was to investigate genome-wide mRNA expression in adipose tissue in healthy men before and after an exercise intervention to identify genes or pathways that mediate the beneficial

As wintering Whooper Swans Cygnus cygnus have shiftedtheir winter feeding habitats from water to terrestrialones, the International Waterfowl Counts, covering onlycoastal and lake sites since its start in 1967, cannot monitortrue population change. Therefore, special surveyscovering also the terrestrial habitats have been organizedin mainland NW Europe every ive years since 1995. InJanuary 2015, a

Limestone samples from the Cambro-Ordovician Durness Group were crushed, aciddigested and searched for evidence of micrometeorites. Eleven melted micrometeorites were extracted from the magnetic fraction of samples from the Balnakeil and Croisaphuill formations near the top of the group. Other formations in the Durness Group did not yield micrometeorites. Only melted spherules with a distinctive d

Voices from within the victim movement express a need for morality to have fixed boundaries between good and evil, right and wrong. However, such a morality is not always easy to define and uphold. It is thought important to consider the victims particular experiences, through another logic and morality than the strictly legally defined. This dissertation studies victim support as a moral definiti

Minimum variance control of difference equations systems with time-varying stochastic parameters are studied. The optimal control law is derived under the assumption that all previous, but not the current parameter values are known. This is used to give performance limits for dual control. In particular, it is shown that too much parameter uncertainty may cause the system to be unstable in the sen

Meteorologi är ett område som genomgick utveckling under 1900-talet. Det har gått från att vara väldigt erfarenhetsbaserat till att bestå av komplexa matematiska modeller som körs av superdatorer. Ett av de mer nyliga tilläggen är ensembleprognoser. De började användas operativt 1992 av European Centre for Medium-Range Weather Forecasts (ECMWF). En ensembleprognos är uppbyggd av ett flertal model

Det internationella immaterialrättsliga rättssystemet har etablerats på grundsatsen att immaterialrättigheter är territoriella och därmed begränsade sett till innehåll och omfång till respektive skyddsland. Den territoriella begränsningen bekräftas av bl.a. Bernkonventionen och Pariskonventionen på området och är väl förankrad i svensk rätt, dock väldigt sällan i lagtext. Eftersom immaterialrättig