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Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis, and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1. Loss of Clec16a leads to an increase in the Nrdp1 target Parkin, a master regulator of mitophagy. Islets from mice with pancre
The polychaete annelid Kingnites diamondi, a new paulinitid genus and species, is described from the Silurian of Baltoscandia. Its large maxillae differ morphologically from those of all other known paulinitids, particularly in being very elongate and having conspicuous myocoele openings and posterior portions of the first maxillae (MI). Albeit rare, this polychaete taxon is highly characteristic
Within the family of voltage-gated calcium channels (VGCCs), L-type channels (L-VGCCs) represent a well-established therapeutic target for calcium channel blockers, which are widely used to treat hypertension and myocardial ischemia. L-VGCCs outside the cardiovascular system also control key physiological processes such as neuronal plasticity, sensory cell function (e.g. in the inner ear and retin
The rising global prevalence of diabetes mellitus is accompanied by an increasing burden of morbidity and mortality that is attributable to the complications of chronic hyperglycaemia. These complications include blindness, renal failure and cardiovascular disease. Current therapeutic options for chronic hyperglycaemia reduce, but do not eradicate, the risk of these complications. Success in defin
The estrogen receptor beta (ER beta) is emerging as an important player in the physiology of the endocrine pancreas. We evaluated the role and antidiabetic actions of the ER beta selective agonist WAY200070 as an insulinotropic molecule. We demonstrate that WAY200070 enhances glucose-stimulated insulin secretion both in mouse and human islets. In vivo experiments showed that a single administratio
Objective - To determine if the dipeptidyl peptidase 4 inhibitor vildagliptin more effectively than the sulfonylurea glimepiride inhibits glucagon levels during meal. Research design and methods - Glucagon responses to a standard meal were measured at baseline and study endpoint (mean 1.8 years) in a trial evaluating add-on therapy to metformin with vildagliptin 50 mg bid compared to glimepiride u
In this study, a three-phase hollow fiber liquid-phase microextraction (HF-LPME) method combined with liquid chromatography-mass spectrometry was developed for direct determination of four non-steroidal anti-inflammatory drugs (ketoprofen, naproxen, diclofenac and ibuprofen) in sewage sludge. The drugs were extracted from non-spiked and spiked slurry samples with different amounts of sludge into a
OBJECTIVE - To compare the sensitivity and specificity of luciferase immunoprecipitation (LIPS) with radioimmunoprecipitation (RIP) for the measurement of autoantibodies to the type 1 diabetes autoantigens glutamic acid decarboxylase 65 (GAD65) and insulinoma-associated protein (IA)-2 beta. RESEARCH DESIGN AND METHODS - Sera from 49 type 1 diabetic patients and 100 nondiabetic control subjects fro
We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously
There is little research on the personalities and emotional stability of persons who report being bullied or witnessing bullying at work. Men and women (N = 247) from 19 to 64 years of age and in manual labour completed a questionnaire concerning the psychosocial work climate, bullying and personality. Three groups were defined: bullied (N = 14), witnesses (N = 31) and non-bullied respondents (N =
I denna artikel analyserar muntligt gestaltade erfarenheter hos före detta lägerfångar som placerades i koncentrationsläger i början av kriget i Bosnien och Hercegovina under 1990-talet. Artikeln bygger på 13 intervjuer med före detta lägerfångar och nära anhöriga som numera bor i Sverige, Danmark och Norge. Syftet med artikeln är att beskriva de sociala interaktionsritualer som återberättas efter
It is hypothesized that nonverbal behaviors of team sport athletes have an important impact on the course of the game. However, quantitative research on this topic is rare, partly due to a lack of scientifically sound coding schemes developed to assess nonverbal behavior in team sports. The aim of the present study is to develop a coding scheme that measures nonverbal behaviors displayed by female
