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From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-ba
The Middle Ordovician of the palaeocontinent Baltica provides some of the best preserved and most diverse acritarch assemblages of the lower Palaeozoic. A great number of widely used acritarch genera and species have been described from this area since the 1960s and many of these taxa are considered as biostratigraphically useful for both regional and international correlation. Here, we document t
We investigated the molecular mechanisms of exercise adaptations in human muscle by integrating genome, methylome, transcriptome, and proteome data from over 1,000 participants (2,340 muscle samples). We identified distinctive signatures associated with maximal oxygen consumption (VO2max), and multi-omics integration uncovered five key genes as robust exercise markers across layers, with transcrip
Emerging evidence from diverse populations highlights the therapeutic benefits of the Crohn’s Disease Exclusion Diet (CDED) in managing Crohn’s Disease. To improve the efficacy of the CDED, there is a need to focus on cultural adaptation and individualization to support dietary adherence to this advanced nutritional therapy. This paper provides a theoretical framework for modifying the CDED to ali
Comprehensive screening of the general population is the only approach capable of identifying the majority of cases with celiac disease. In 2023, the Italian Parliament enacted a law to implement nationwide screening for celiac disease and type 1 diabetes. However, critical decisions regarding the target population, optimal timing, and screening methods remain unresolved. Previous observational st
This paper provides micro-level evidence of how and why functional lock-ins persist, despite clear articulations of cognitive un-locking at firm, cluster and regional levels. Theoretically, we draw on literature on regional clusters and vertical value chains to consider how incumbent firms’ efforts to diversify are conditioned by regional lock-ins as well as value chain governance. To investigate
During the last few years Europe has made enormous progress towards free electron laser (FEL)-based research infrastructures. The FLASH facility [1] at DESY in Hamburg, Germany, has been in user operation since the summer of 2005; FERMI@Elettra [2] in Trieste, Italy, is under construction; the European XFEL [3] in Hamburg will start construction in summer 2008; and several other FEL projects are b
In recent years, trust has emerged as a topic of interest for scholars aiming to understand the mechanisms enabling transnational intelligence cooperation and focusing on relations of trust between intelligence agencies. The potential dynamics between the trust facilitating transnational intelligence cooperation and the public trust in intelligence agencies on a national level, however, remains un
