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Soluble Urokinase Plasminogen Activator Receptor is Associated With Inflammation in the Vulnerable Human Atherosclerotic Plaque.

Recently, plasma soluble urokinase plasminogen activator receptor (suPAR) has gained interest as a marker of cardiovascular risk. suPAR is released through the cleavage of urokinase plasminogen activator receptor (uPAR), which is found in monocytes, activated T-lymphocytes and endothelial cells, all involved in atherosclerosis. suPAR levels have been well studied in plasma, but no studies have foc

Glucolipotoxicity alters insulin secretion via epigenetic changes in human islets

Type 2 diabetes (T2D) is characterized by insufficient insulin secretion and elevated glucose levels, often in combination with high levels of circulating fatty acids. Long-term exposure to high levels of glucose or fatty acids impair insulin secretion in pancreatic islets, which could partly be due to epigenetic alterations. We studied the effects of high concentrations of glucose and palmitate c

The effect of marketing messages on the motivation to reduce private car use in different segments

This study explores marketing messages promoting sustainable transport and reported motivation to reduce private car use within different segments. A stated preference survey targeting a sample of 1300 residents in Sweden was conducted, and exploratory factor analysis was used to identify underlying dimensions of a set of 19 marketing messages. Self-efficacy and collective efficacy were defined as

The ICOS Atmosphere use case : From raw data to knowledge of societal relevance

In order to effectively tackle the on-going changes in global climate, stakeholders and policy makers across the globe need timely and accurate information they can trust on a wide range of topics. Here we briefly describe how observational data on greenhouse gas concentrations collected from the ICOS network of measurement stations in Europe is transformed via atmospheric modelling into informati

The role of citrulline, intestinal fatty acid–binding protein, and D-dimer as potential biomarkers in the diagnosis of internal herniation after Roux-en-Y gastric bypass

Background: Diagnosing internal herniation (IH) in Roux-en-Y gastric bypass (RYGB) patients with acute abdominal pain poses a diagnostic challenge. Diagnostic laparoscopy is often required for a definitive diagnosis. We hypothesized that intestinal ischemia biomarkers would aid in the diagnosing of IH. Objectives: To explore intestinal ischemia biomarkers in diagnosing IH. Setting: University Hosp

A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use—The P5 Study

We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their

The new geographies of popular music (in a pandemic) : Guilty geographies and compressed intimacies

In this paper, I analyse developments in the relationship between popular musicians and their audiences that have intensified during the COVID-19 pandemic of 2020–21. The first, guilty geographies, concerns musicians and music venues becoming increasingly reliant on charitable audience support, appealing to fans’ ethical consciences through the crowdfunding (or fan-funding) model. The second, comp

Can simple advice eliminate the gender gap in willingness to compete?

As a recent literature has demonstrated, men and women differ in their willingness to sort into competitive environments. In particular, men are more willing than women to compete. We investigate whether it is possible to reduce the gender gap in willingness to compete through an information intervention that informs participants of the gap and advises them about the potential earnings implication