The leading cause of morbidity and mortality worldwide is atherosclerotic cardiovascular disease, most commonly caused by rupture of a high-risk plaque and subsequent thrombosis resulting in stroke, myocardial infarction or sudden death depending on the affected arterial territory. Accurate, non-invasive methods to identify such lesions known as vulnerable or high-risk plaques are currently sub-op

Remote laser-induced fluorescence monitoring can complement passive reflectance measurements on vegetation. Vegetation classification and status assessment is normally performed by air- or spaceborne multi-spectral scanners. An increased research activity in the field of vegetation monitoring is motivated by the abundant stressed forests of Europe. We have used a mobile lidar system for remote stu

The investigation of memory distortions provides insights into how memory normally works. Adopting a cognitive neuroscience perspective, the present thesis aimed at investigating memory distortions and the neural correlates of processes contributing to successful control of memory interference in healthy participants. All studies employed variations of the modified continuous recognition task. In

Many deaths in intensive care units are preceded by decisions to withhold or withdraw life-sustaining treatment. Under what conditions are forgoing life-sustaining treatment considered appropiate, when is it optitional and when is it wrong? Relevant guidelines are essential to help medical decisionmakers, but they cannot be established only from medical knowledge. They also must be related to basi

In this paper I give a short presentation of a syntactic approach to argument structure, taking a particular implementation of the minimalist framework (Chomsky (1995, 2001 and later)) as my point of departure. The proposed account allows for only 16 different argument structures, thereby reducing the syntactic variation at this level of syntax considerably. The theory also offers an explanation w

The small intestine contains a large number of T lymphocytes within the single-layered epithelium that separates the gut lumen from the lamina propria. These intraepithelial T lymphocytes have potent cytolytic and immunoregulatory capacities, thought to be important for fighting infections, neoplastic growth, and sustaining epithelial integrity. This thesis is based on three original articles wit

As a result of the globalisation of the world economy, many enterprises that previously confined their business activities to national markets are now focusing on broader international markets, thus forming the basis for the establishment of global enterprises. In addition to the extension of markets, these global companies also seek cost reductions through scale economics in logistics, marketing,

Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8+ T cells. The peptides are generated by proteasomes in the cytosol, then translocated across the membrane of the endoplasmic reticulum (ER) by the transporter associated with antigen processing (TAP). Only properly assembled class I molecules loaded with high affinity peptides reach the cell surface. The mat

Pancreatic enzymes, neutrophils, free radicals and cytokines are involved in the pathophysiology of AP. Clarification of their interaction and time-course will improve our understanding of AP and provide a better basis for treatment. 20% will develop severe AP and benefit from improved treatment why an accurate test for prediction of severity is needed. Aims: To investigate the interactions betwee

HOXB4 is one of 39 members of the homeobox (HOX) family, a family of transcription factors involved in embryonic development. Several HOX transcription factors, including HOXB4, are highly expressed in hematopoietic stem cells (HSCs) but are downregulated upon differentiation towards more mature progeny cells. Enforced expression of HOXB4 dramatically increases the regeneration of murine HSC follo

Hormone-sensitive lipase (HSL) has a wide tissue distribution with the highest expression found in white adipose tissue (WAT). HSL also has a unique ability to hydrolyze a large panel of substrates including acylglycerols, cholesteryl esters and retinyl esters. HSL is potentially a new drug target for the treatment of obesity and type II diabetes. However, as HSL is not only expressed in adipose t

Alzheimer's disease (AD) is the most prevalent type of dementing disorder. The cortical pathology of AD has been recognized for almost a century. In later years, an associated pathological feature of AD has been identified which affects the white matter. This white matter disease (WMD), defined in the microscope, consists of a subtotal tissue loss of the white matter structural components. WMD is

The aim of this report is to present some of the variable uncertainties associated with the dimensioning of fire protection in buildings and risk analysis in buildings (with respect to fire). A method for assessing the fire frequency in a building is presented along with examples of how the assessed fire frequency can be improved using fire data from a specific building. The probability of differe

Background: Stroke is one of the major causes of disability in the adult population and represents a heavy social and economic burden. Currently available therapeutic tools to support the recovery of impaired brain functions are quite limited. Animal studies have demonstrated that neuronal replacement and partial reconstruction of neural circuitry or modulation of the recovery process is possible

Denna doktorsavhandling undersöker samtal om personliga problem i mötet med en specialist i radio. I synnerhet handlar studien om den dynamiska process då förståelse skapas – när upplevelser av personliga bekymmer förklaras och definieras som problem av särskilda slag. Denna meningsskapande process undersöks i detalj så som den utspelar sig i dialoger i radio och mellan programdeltagare och radiolThe dissertation examines how personal troubles are talked about in an encounter with a professional on the public arena of radio broadcasting, where the professional has to meet the challenge of making professional advice not only useful for the person seeking help, but also relevant or interesting for the radio audience. The study explores the dynamic process of shaping an understanding of probl