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The general objective of the present thesis work was to examine 3-dimensional structure as well as the motional properties of two different types of two-domain proteins by solution-state NMR. One of the major tasks of this thesis work was to investigate the domain orientation of these molecules by employing residual dipolar couplings (RDC) which can be used as orientational restraints for increasi
This thesis is based on work studying the immunoregulatory mechanisms that govern the balance between activation and inactivation of T lymphocytes. Most of the work has been carried out in an experimental system using a T cell receptor (TCR-Vb3) transgenic mouse strain to obtain a homogenous T-cell population and utilizing the properties of bacterial superantigens to induce T cell responses and un
Most energy behaviour studies on households focus on the questions how and why we use energy and what can be done to lower energy consumption. Very few studies raise the question of when energy is used or examine the underlying explanations to load patterns. Due to economic and technical problems with electricity peak load, it is important to gain knowledge about how the load patterns of household
Objective. To describe factors associated with the development of stroke during long-term follow-up after acute myocardial infarction (AMI) in the LoWASA trial. Patients. Patients who had been hospitalized for AMI were randomized within 42 days to receive either warfarin 1.25 mg plus aspirin 75 mg daily or aspirin 75 mg alone. Design. The study was performed according to the probe design, that is
Severely deficient activity of the von Willebrand Factor (VWF) cleaving metalloprotease,ADAMTS 13, is associated with thrombotic thrombocytopenic purpura (TTP). The mutation spectrum ofADAMTS 13 is rather heterogeneous, and numerous mutations spread across the gene have been described in association with congenital TTP. The 4143insA mutation is unusual with respect to its geographic concentration.
Background: There is a shortage of reports on what potential recipients of implantable cardioverter-defibrillators ( ICDs) need to be informed about and what role they can and want to play in the decision-making process when it comes to whether or not to implant an ICD. Aims: To explore how patients with heart failure and previous episodes of malignant arrhythmia experience and view their role in
Background. Ethical issues arise in many obstetric situations and demand constant consideration by obstetricians. The aim of this study was to highlight the meaning of being in an ethically difficult situation as narrated by obstetricians. Methods. A descriptive design with a qualitative approach using a hermeneutic phenomenological method for analysis. Interviews were performed with 14 obstetric
A sample of Ap and Bp stars have been investigated with respect to theirsurface magnetic field using synthetic spectrum fitting. The advantageof this technique is the simplicity in determining the surface fieldstrength and the possibility to apply it to objects whose spectrum doesnot display resolved Zeeman components. We show the usefulness of themethod by demonstrations on stellar spectra with r
Antisocial behavior is often persistent, and in addition to causing suffering to children and their families, it also poses considerable costs for society. Children who display externalizing behavior in their early years run a high risk of having severe problems later in life. There is a need for treatment methods that may be used in various settings because these children constitute a group that
The aim of this paper is to compare general assumptions about newspaper reading with eye tracking data from readers authentic interaction with the newspaper. In the first step, we extract assumptions about newspaper reading from the (socio)semiotic literature. Second, we apply these assumptions in an analysis of a newspaper spread. The newspaper spread is analysed without any knowledge of the actu
Popular AbstractWhen society first perceived the environmental condition as problematic, focus was on local emissions with local consequences. Subsequently, the center of attention partly moved beyond local effect research to a broader interest in, for instance, ecocycle processes of energy, and the whole lifecycle of materials. However, technological and natural scientific analyses of these pheno
Background: The coexistence of cataract and age related macular degeneration (AMD) is not unusual, especially in the very elderly. The outcome of cataract surgery in these cases depends on the effect of AMD on vision. In this study the authors have compared the outcome of cataract patients with AMD to that of cataract patients with no vision threatening ocular comorbidity, and analysed possible pr
