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While priority setting for research, development and innovation (RDI) traditionally focuses on which thematic areas should be supported, less is known about how such goals are implemented on the agency level. Key challenges are how to translate broad priorities into programs and projects, how to govern the knowledge base, and how to handle organizational tensions during implementation. Many of the
Type 2 diabetes is a complex trait with both environmental and hereditary factors contributing to the overall pathogenesis. One link between genes, environment, and disease is epigenetics influencing gene transcription and, consequently, organ function. Genome-wide studies have shown altered DNA methylation in tissues important for glucose homeostasis including pancreas, liver, skeletal muscle, an
Apolipoprotein A-I (apoA-I) in high-density lipoprotein (HDL) provides cardiovascular protection. Synchrotron radiation circular dichroism (SRCD) spectroscopy was used to analyze the dynamic solution structure of the apoA-I protein in the apo- and HDL-states and the protein structure conversion in HDL formation. Wild-type apoA-I protein was compared to human variants that either are protective (R1
There are many advantages of combining incretin therapy [glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors] with insulin therapy as a glucose-lowering strategy in type 2 diabetes. One important advantage is the complementary mode of the mechanistic action of incretin and insulin therapy. Another advantage is the reduction in risk of hypoglycemia and we
Prurigo nodularis is a pruritic condition characterized by skin noduli. Different treatment options have been used with limited success. Pregabalin is a drug licensed for treatment of neuropathic pain in adults. As prurigo nodularis involves suffering for the patients and is difficult to treat, the aim of this case report is to report the effect of pregabalin treatment in seven patients with pruri
As shown by transgenic mouse models and by using phosphodiesterase 3 (PDE3) inhibitors, PDE3B has an important role in the regulation of insulin secretion in pancreatic β-cells. However, very little is known about the regulation of the enzyme. Here, we show that PDE3B is activated in response to high glucose, insulin and cAMP elevation in rat pancreatic islets and INS-1 (832/13) cells. Activation
Socially the context of archaeology is supposed to have travelled from kings, princes and aristocracy down to the bourgeoisie and the middle class. However members of the royal family still have a central role as it is seen from the current exhibition “Queen Margrethe II and archaeology” on Moesgård Museum at Århus and the National Museum in Copenhagen. The aim is here to examine the royal archaeo
It is widely accepted that firms in peripheral regions benefit to a lesser extent from local knowledge spillovers than firms located in agglomerations or industrial clusters. This paper investigates the extent to which innovative firms in peripheral regions compensate for the lack of access to local knowledge spillovers by collaborating at other geographical scales. So far the literature predomina
The new European Commission took office on 1 November 2014, with a number of structural changes including the creation of a First Vice-President, a responsibility given to the former Dutch Foreign Minister Frans Timmermans. The First Vice-President will ensure that every Commission proposal respects the principles of subsidiarity and proportionality. If the Commission pays more attention to the pr
This book provides the reader with a broad policy analysis of a main set of tools aimed at realising an increasingly appreciated aspect of late modern democracy: green political consumerism. The authors illustrate and explain how green labels and other eco-standards are created and negotiated within a broad continuum between science and politics, by addressing political, regulatory, discursive, an
Abstract [Bryophyes in base-rich fens in Skåne, southern-most Sweden, now and in the past] Over the last centuries, due to the combined effects of drainage, cultivation, eutrophication and overgrowth, the majority of all tree-less base-rich fens that were once found in Skåne have been lost and the typical species of these habitats have suffered accordingly. Here, the past and present distribution
Recent research on public transport has seen increasing focus on issues like coordination, collaboration and steering in complex governance settings. One of the themes in this field of research is related to partnership approaches, as one way of stimulating functioning collaboration between formally independent private and public organisations. The aim of this paper is to explore the role and func
