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Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,1

Parsifal in exile: Wagner's 'Bühnenweihfestspiel' as it was patronized and perfomed in exile, 1933-1945

I understand patronage principally as a work of cultural and material support - the support shich was necessary to stage the performance of a piece of music in mayn different contexts. I focus on the fate of an opera, Richard Wagner's Parsifal, a work which was not performed at the Bayreuth festival between 1939 and 1944 because of its emphasis on reconciliation, non-violence and faith, but which

Breastfeeding does not influence the development of inhibitors in haemophilia.

Our aim was to test the hypothesis that breastfeeding may reduce development of inhibitors in male infants with haemophilia by inducing an oral immune tolerance to factor VIII. To achieve that goal, we performed a structured epidemiological survey comprising all males born with severe haemophilia A (in all 100 patients, 19 with inhibitors) or haemophilia B (in all 16 patients, six with inhibitors)

Previous experimental studies and field measurements on moisture buffering by indoor surface materials

An increased interest in moisture buffering in the indoor environment and the development of more refined hygrothermal calculation tools call for a better understanding of the phenomenon. There are many materials indoors with potential to act as moisture buffers, ranging from traditional finishing materials as gypsum plaster to textiles. The objective of this study is to show that the interest in