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Science originates knowledge and downstream innovation. “Big” science is likely to, along the line, give rise to “big” innovation. Large research infrastructures are characterized by containing a large number of partners involved in complex networks of internal and external collaborations. This chapter explores how large research infrastructures (broadly defined) manage internally and externally t
The recent debate on innovation-based structural change in Evolutionary Economic Geography is characterised by a strong focus on the rise of new industrial paths. This paper seeks to shift attention and cast light on radical innovation activities occurring within existing paths without necessarily leading to their dissolution. Departing from a systemic perspective of path development we propose a
In the Western world, gender/sex is traditionally viewed as binary, with people falling into one of two categories: male or female. This view of gender/sex has started to change, triggering some resistance. This research investigates psychological mechanisms underlying that resistance. Study 1 (N = 489, UK) explored the role of individual gender identification in defense of, and attempts to reinfo
Categorising people and housing situations is unavoidable in research and national and local statistics on homelessness, as well as in regulating and planning for interventions and supply and allocation of suitable accommodation. Despite different motives and original functions, however, these categories and the use of them are influenced by the political discourse, especially when they travel froCategorising people and housing situations is unavoidable in research and national and local statistics on homelessness, as well as in regulating and planning for interventions and supply and allocation of suitable accommodation. Despite different motives and original functions, however, these categories and the use of them are influenced by the political discourse, especially when they travel fro
Emergence agitation following anesthesia in children is not uncommon. It is, although generally self-limiting, associated with both patient and parents distress. We conducted a national survey around the management of behavioral and neurocognitive disturbances after surgery/anesthesia including a case scenario about a child at risk for emergence reaction. Premedication with clonidine or midazolam
Beam line optics for synchrotron facilities are generally designed from geometric calculations wherein the bending magnet, undulator, or wiggler photon source is approximated by a high divergence point source. In this article we will, however, show that in the case of a synchrotron radiation source with very small divergence (such a source can be encountered at an undulator based third generation
Foreign investors in the Nordic countries are most likely to find country risk arising from problems on the supply side, as in corporate structural changes. Such changes manifest themselves in a tendency toward concentration and internationalization on the macroeconomic level. Country risk can be divided into political risk and the risk of suspended payments, both of which are directly related to
Proton-induced X-ray emission, PIXE, is capable of simultaneous quantitative determination of 10-15 elements. An introduction to the physical properties of the method is given and detection limits are shown for a routine analysis of a thin aerosol sample. Examples of applications to both thick and thin samples are presented. Human tooth dentine is analysed for lead, with simple sample preparation,
There are many advantages of combining incretin therapy [glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors] with insulin therapy as a glucose-lowering strategy in type 2 diabetes. One important advantage is the complementary mode of the mechanistic action of incretin and insulin therapy. Another advantage is the reduction in risk of hypoglycemia and we
Prurigo nodularis is a pruritic condition characterized by skin noduli. Different treatment options have been used with limited success. Pregabalin is a drug licensed for treatment of neuropathic pain in adults. As prurigo nodularis involves suffering for the patients and is difficult to treat, the aim of this case report is to report the effect of pregabalin treatment in seven patients with pruri
As shown by transgenic mouse models and by using phosphodiesterase 3 (PDE3) inhibitors, PDE3B has an important role in the regulation of insulin secretion in pancreatic β-cells. However, very little is known about the regulation of the enzyme. Here, we show that PDE3B is activated in response to high glucose, insulin and cAMP elevation in rat pancreatic islets and INS-1 (832/13) cells. Activation
Socially the context of archaeology is supposed to have travelled from kings, princes and aristocracy down to the bourgeoisie and the middle class. However members of the royal family still have a central role as it is seen from the current exhibition “Queen Margrethe II and archaeology” on Moesgård Museum at Århus and the National Museum in Copenhagen. The aim is here to examine the royal archaeo
Human milk contains a vast array of bioactive molecules, with nutritional and protective functions. This thesis describes the effects of a human milk protein complex, MAL, on tumour cells and bacteria. During our studies on the anti-adhesive properties of human milk we observed that a milk fraction killed tumour cells. The morphology of the cells indicated apoptotic cell death and this was verifie
