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Din sökning på "swedish" gav 92132 sökträffar

Pancreatic β-cell mRNA modification as a marker for type 2 diabetes

Diabetes mellitus invariably involves impaired regulation of insulin secretion from pancreatic β cells, as a result of unfavourable environmental influences in combination with aberrant expression of risk genes at either the transcriptional or the translational level. A recent report in Nature Metabolism explores a novel role of mRNA methylation in β-cell function and suggests that its downregulat

Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial

Background New treatment strategies for early rheumatoid arthritis are evolving rapidly. We aimed to compare addition of conventional disease-modifying antirheumatic drugs (sulfasalazine and hydroxychloroquine) with addition of a tumour necrosis factor antagonist (infliximab) to methotrexate in patients with early rheumatoid arthritis. Methods We undertook a randomised trial in 15 rheumatology uni

Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study.

Conflicting evidence exists regarding the association between saturated fatty acids (SFAs) and type 2 diabetes. In this longitudinal case-cohort study, we aimed to investigate the prospective associations between objectively measured individual plasma phospholipid SFAs and incident type 2 diabetes in EPIC-InterAct participants.

Plasma lipid composition and risk of developing cardiovascular disease.

We tested whether characteristic changes of the plasma lipidome in individuals with comparable total lipids level associate with future cardiovascular disease (CVD) outcome and whether 23 validated gene variants associated with coronary artery disease (CAD) affect CVD associated lipid species.

IL-25 Inhibits Atherosclerosis Development in Apolipoprotein E Deficient Mice.

IL-25 has been implicated in the initiation of type 2 immunity and in the protection against autoimmune inflammatory diseases. Recent studies have identified the novel innate lymphoid type 2 cells (ILC2s) as an IL-25 target cell population. The purpose of this study was to evaluate if IL-25 has any influence on atherosclerosis development in mice.

Grammatiken och språknormerna

The article treats the problem why a descriptive grammar cannot avoid from being normative in some ways. some uses of language are always excluded. on the other hand a descriptive grammar should account for competing variants where there might be disagreement among the language users which expression is correct, i.e. should be accepted as norm. The descriptive grammar does not tell which variant i

The palaeolimnological record of regime shifts in lakes in response to climate change

Regime shifts in lake ecosystems can occur in response to both abrupt and continuous climate change, and the imprints they leave in palaeolimnological records allow us to investigate and better understand patterns and processes governing ecological changes on geological time scales. This thesis aims at investigating palaeolimnological records of regime shifts in lakes during the Holocene to explor