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Metabolomics is a growing research field where new protocols are rapidly developed and new applications discovered. Common applications include biomarker discovery and elucidation of drug metabolism. However, the development of such protocols rarely includes a systematic optimization followed by validation with real samples. Here a GC/MS-based protocol using methoximation followed by silylation wi

The cost of treating cardiovascular disease (CVD) and diabetes is enormous and is set to rise in the coming years. Physical inactivity and sedentary behaviors are major risk factors for these diseases and are estimated to account for several million global deaths annually. Lifestyle interventions, particularly those aimed at enhancing physical activity levels, have a substantial favorable impact o

Often in clinical practice, a diagnosis of alcohol dependence or abuse does not provide enough information to establish an adequate treatment plan. Hence, multidimensional instruments have been constructed better to describe the extent and character of a patient's alcohol problem. The purpose of the current article is to present the AVI-R2, a self-report test that provides a standardized and diffe

Insulin is released from pancreatic beta-cells as a result of Ca(2+)-evoked exocytosis of dense-core granules. Secretion is biphasic, which has been suggested to correspond to the release of different granule pools. Here we review and carefully reanalyze previously published patch-clamp data on depolarization-evoked Ca(2+)-currents and corresponding capacitance measurements. Using a statistical mi

This paper examines whether a resident's estimate of five traffic-related phenomena (accident frequency, incident frequency, difficulty of crossing the street, traffic flow, and speed level) in their neighborhood may depend on factors such as gender, age, how frequently they walk along the street or on characteristics of the street. The material consists of survey data from 919 residents living al

Laibl, L., Fatka, O., Budil, P., Ahlberg, P., Szabad, M., Voka, V. & Kozak, V., 24.3.2015. The ontogeny of Ellipsocephalus (Trilobita) and systematic position of Ellipsocephalidae. Alcheringa 39, 477-487. ISSN 0311-5518.Well-preserved early holaspid stages of the Cambrian Series 3 trilobites Ellipsocephalus hoffi (Schlotheim, 1823) and Ellipsocephalus polytomus Linnarsson, 1877 have been disco

In this article, Övdalian null subjects are introduced and analysed. A general background to Övdalian is provided, whereupon the possible null subjects (wįð ('we') and ið ('you')) are presented. Interestingly, these null subjects do not appear in the same syntactic positions; whereas null ið seems to be unrestricted, null wįð may only appear in positions immediately preceding the finite verb. It i

Diabetes is a much more heterogeneous disease than the present subdivision into types 1 and 2 assumes; type 1 and type 2 diabetes probably represent extremes on a range of diabetic disorders. Both type 1 and type 2 diabetes seem to result from a collision between genes and environment. Although genetic predisposition establishes susceptibility, rapid changes in the environment (ie, lifestyle facto

Recent research in entrepreneurship has examined factors that could reduce the challenges facing new businesses (the so-called ‘liabilities of newness’). Seeking to contribute to this research, this study examines the potential role of a financial bootstrapping approach (finding ways of securing resources on favourable terms). Even though financial bootstrapping has received increased attention in