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STUDY QUESTION: Does chemotherapy exposure (with or without alkylating agents) or primary diagnosis affect spermatogonial quantity in human prepubertal testicular tissue? SUMMARY ANSWER: Spermatogonial quantity is significantly reduced in testes of prepubertal boys treated with alkylating agent therapies or with hydroxyurea for sickle cell disease. WHAT IS KNOWN ALREADY: Cryopreservation of sperma
On the banks of the Göta River, the city of Gothenburg is undergoing a transformation that characterizes many urban waterfronts today, as shipping, fishing, and naval uses are replaced by a high demand for new housing. What is unique to Gothenburg is its vision of a RiverCity that is diverse, environmentally sound, and vibrant. It is imperative, however, to take stock of the successes and failures
In the past years Centers of Excellence (CoE) has risen to prominence as a funding instrument in science. The idea is that by focusing resources, people and attention within a center environment, and over a substantial time span, excellence in science can be promoted. Similarly, interdisciplinarity is often seen as an enabling condition or even necessary for frontier research. This article builds
The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular s
In this study, user participation is suggested as a means, a process and role-playing between system users and developers in systems development. User participation in object-oriented contexts is observed from methodological and practical perspectives as a combined field of study. From the methodological perspective, three object-oriented methods are assessed according to NIMSAD, a method evaluati
This study was directed towards personality-related, value system and sociodemographic variables of nursing students in a situation of change, using a longitudinal perspective to measure their improvement in principle-based moral judgement (Kohlberg; Rest) as possible predictors of stress. Three subgroups of students were included from the commencement of the first three-year academic nursing prog
