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Understanding past methane dynamics in arctic wetlands and lakes is crucial for estimating future methane release. Methane fluxes from lake ecosystems have increasingly been studied, yet only few reconstructions of past methane emissions from lakes are available. In this study, we develop an approach to assess changes in methane availability in lakes based on delta C-13 of chitinous invertebrate r

IMPORTANCE The introduction of biological tumor necrosis factor inhibitors has improved the treatment of rheumatoid arthritis (RA) but at a substantial cost. These drugs have been shown to lead to superior radiological outcomes compared with a combination of conventional disease-modifying antirheumatic drugs over 2 years. OBJECTIVE To investigate whether radiological superiority translates into be

The subject of this thesis is the activated protein C (APC)-mediated inactivation of factor Va. The activated form of factor V (FVa) is a procoagulant cofactor for Factor Xa (FXa) in the conversion of prothrombin to thrombin. The procoagulant function of FVa is down regulated by APC through proteolytic cleavage at three sites, Arg306, Arg506 and Arg679. The cleavage at Arg506 is kinetically favore

Declines in the distribution and abundance of many farmland species during recent decades have been attributed to agricultural intensification. Agri-environment schemes are commonly used in Europe to reduce this loss of farmland biodiversity, but their effectiveness may depend on several external factors. In this thesis, I have used one such scheme, organic faming, as a landscape scale experiment

Islands are cradles for new biodiversity and provide natural laboratories for the study of population divergence. In my thesis, I investigated the role of different evolutionary processes in the population divergence in the Skyros wall lizard (Podarcis gaigeae), a species where islet populations have strongly diverged morphologies. I used replicate islet populations and their respective most proxi

In man, the urinary bladder responds to an urinary outflow obstruction with a pronounced dilatation and growth of the bladder wall. This clinical situation can be mimicked in rat by creation of a partial urinary outflow obstruction and the papers included in the present thesis use this animal model to address questions regarding the adaptive changes in the smooth muscle of the growing bladder. In

Rheumatoid arthritis (RA) is characterized by persistent inflammation, progressive joint damage and disability. This thesis describes the outcome after 10 years in a cohort of 183 RA patients (116 women, 67 men) recruited 1985-89. The mean age was 51 years and symptom duration 11 months at inclusion. Standardized clinical, biochemical and radiographic assessments were performed annually. Health st

We have followed a cohort of police officers in Guinea-Bissau between 1990 and 1997 for the study of clinical, immunological and epidemiological aspects of HIV-2 infection. Initially the prevalence of HIV-2 was high (11.6 %) and HIV-1 infection was rare (0.4 %), but over the study period the prevalence of HIV-1 increased significantly whereas the incidence of HIV-1 was relatively stable. For HIV-2

As a result of the globalisation of the world economy, many enterprises that previously confined their business activities to national markets are now focusing on broader international markets, thus forming the basis for the establishment of global enterprises. In addition to the extension of markets, these global companies also seek cost reductions through scale economics in logistics, marketing,

In this paper, cultural transmission between Slavs and Scandinavians from ca 900 to 1250 is discussed. Cultural identity and identity negotiation through style are topics often studied in higher social strata of societies. Emblemic style is maintained and displayed in jewellery or other eye-catching parts of the material culture to distinguish oneself in relation to others. However, the constructi

The progressive process of tumour invasion and generation of metastases is the primary cause of death for most patients with cancer. Some of the regulatory components of this progressive process are adhesion, migration, and proteolysis. Urokinase -type plasminogen activator (u-PA) is a serine protease associated with tissue remodelling, cellular invasiveness, matrix degradation, angiogenesis, and