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Treatment with warfarin in combination with clopidogrel has been shown to reduce the incidence of major bleeding as compared to triple antithrombotic therapy (TT; warfarin, clopidogrel and aspirin). However, there are uncertainties regarding the risk for thrombosis since poor-responsiveness to clopidogrel is common. Ticagrelor is a more potent platelet inhibitor, but data supporting concurrent use
There is concern over the high risk of cardiovascular complications, hypertensive disorders, and other adverse obstetric outcomes among pregnant women with Turner syndrome (TS). A diagnosis of TS is made in some women late in life or not at all. Spontaneous pregnancies are rare in women with TS and are associated with a high rate of complications, especially miscarriage. The use of assisted reprod
It is well known that nature offers an abundance of materials and processes that can be adapted in low-tech fashion, to fabricate systems capable of removing pollutants from wastewater. During the last decade, extensive basic and engineering research on such natural treatment systems have led to improvement of the quality of discharged wastewaters. However, the mechanisms of natural treatment and
The family with the elderly and the home help workers’ team constitute two organisations, which meet in the care work. In this context the family is extended and often constitute not only members from the nuclear family but also other members of the network of relatives, whom take part in the care of the elderly. The extended family may in some cases include four generations (Finch & Mason, 19
Zabrze is a medium size town of 200 000 inhabitants in the region of Upper Silesia, Poland. The development of the town was originally based on the exploitation of heavy industries. In the past few years Zabrze has, however, moved towards more service and tourism oriented industries. As part of this journey, the city of Zabrze sees the need to improve its existing waste management system. This rep
A sustainable development of the built environment asks for changes in urban residents’ mobility patterns. The extensive use of the car contributes to sedentary lifestyle and negative environmental impact in many respects. Children living in urban areas are faced with limits of their independent use of the environment both in terms of travel and outdoor play. Many parents hold favourable attitudes
Context Recent reports suggest that rheumatoid arthritis (RA) may be a risk factor for venous thromboembolism (VTE), particularly in conjunction with hospitalization. Using hospitalization data to identify RA and VTE may identify patients when they are at elevated risk for other reasons, obscuring the incompletely understood underlying association between RA and VTE and leading to inappropriate in
During the last decades, there has been concern that the environmental contaminants, such as POPs, may contribute to sex ratio changes in offspring of exposed populations. Accidental exposure to TCDD has been shown to be associated with fewer sons in men who were exposed in adolescence or earlier in life. However, it is not known whether POPs could change the proportion of X- and Y-sperm. A variet
Abstract The aim of this thesis was to perform health economic analyses of lifestyle intervention for people at a high risk of cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM). The results can help decision-makers to make informed decisions over implementing lifestyle intervention, taking several dilemmas into consideration. Paper I provides evidence on the cost-effectiveness of
