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Concentrations of prostate-specific antigen (PSA) and human kallikrein 2 (hK2) were investigated in blood samples that had been obtained from men who were diagnosed with prostate cancer (PCa) decades later. The studies were based on a cohort comprising 22,444 men who, in 1974?1986, were early middle aged and represented a non-PCa-screened population. The results clearly demonstrate a very strong c

In adult soft tissue sarcoma (STS) of the extremities and trunk wall, improved prognostic factors are needed to identify patients at high-risk for metastasis. Various factors are included in the many prognostic systems currently in use and the prognostic value of immunohistochemical (IHC) expression of biological markers is unclear. The tissue-preserving, high throughput tissue microarray (TMA) te

The Driving to Learn project explored possible achievements of training people with cognitive disabilities in a joystick-operated powered wheelchair utilizing the grounded theory approach. Theoretical sampling led the concomitant collection and analysis of data. During a period of 12 years, 45 participants with profound cognitive disabilities, aged 12 months to 52 years, were engaged in the projec

The general aim of this thesis was to characterize hematologic malignancies using gene expression profiling in order to obtain an improved classification and to study deregulated transcriptional networks in leukemia. In the first study (Article I), the gene expression profiles of hematologic cell lines were analyzed to investigate whether such cell lines maintain expression profiles that are chara

Popular AbstractSveriges första stora kärnkraftsreaktor togs i bruk 1972. Samma år kom kärnkraften att för första gången på allvar ifrågasättas i den svenska riksdagen. Under loppet av ett par år förvandlades kärnkraftsfrågan till den nutida svenska politikens kanske mest kontroversiella och omdebatterade fråga. I denna avhandling analyseras den riksdagspolitiska debatten om kärnkraften mellan åre

In this thesis, different optical methods utilising visible light for characterization of tissue have been developed and evaluated. The feasibility of many of these methods has been demonstrated in the laboratory or in animal experiments. However, the goal is naturally to develop methods useful in the clinic, and thus the emphasis in this thesis has been put on in vivo examinations. Raman spectro

Children with severe diseases can be provided nutritional support through a gastrostomy if needed. At the Department of Paediatric Surgery in Lund we have used the Video Assisted Gastrostomy (VAG) procedure since 1994 when establishing gastrostomies. In this thesis, children with different diseases, who all had undergone the VAG procedure, were studied in five different clinical studies. Postopera

The adverse effects of drugs in the eye are not easily detected, and the underlying pathogenesis not fully understood. The effects of four different kinds of drugs have been investigated in the rabbit eye, using electroretinography, ocular examination and histochemical methods. Rifabutin is a broad spectrum antibiotic with known ocular adverse effects (corneal opacities, uveitis and vascular ret

Anaerobic digestion of organic matter results in the production of biogas, which can be used to replace fossil fuels. There is potential for increased biogas production at wastewater treatment plants by digesting urban organic waste either separately or together with the sludge. Biogas production could also be increased by sludge pre-treatment. The objective of this work was to evaluate the poten

The idea of phosphorus removal at wastewater treatment plants is to transfer dissolved phosphorus into a solid phase. Together with the rest of the produced sludge it is then removed from the water, resulting in a decreased concentration of phosphorus in the effluent and the prevention of the eutrophication in the recipient. Phosphorus can either be stored biologically, with enhanced biological p

The overall aim of this prospective observational study with a salutogenic approach was to investigate bone mineral density (BMD) and BMD changes in the heel bone, in a group of healthy women, in relation to physiological factors and lifestyle behaviours over a two-year period as well as investigating the women’s view of their lifestyle behaviours. Data were collected in 1999 (T1) and 2001 (T2). H

The aim was to study the epidemiology of chronic pain (> 3 months duration) and factors associated to pain prevalence, prognosis, health care and medication in a general population. A cross-sectional mailed survey to a random population sample (n = 1806) was followed by a clinical examination and a prospective study of three selected groups. Pain related diagnoses from primary health care was moni

Almost all northern forest tree species live in symbioses with ectomycorrhizal fungi (EMF). The trees allocate up to half of the photoassimilated carbon (C) through the roots to EMF. In return EMF deliver nutrients from both inorganic and organic sources in the soil, as well as water. Most of the nutrients trees need are assimilated through EMF, which thus play a potentially important role in reta