Sökresultat

T1D is most common in children and young adults and is characterized by autoimmune destruction of insulin producing pancreatic beta cells, presence of certain risk genotypes such as HLA-DQB1, INS VNTR, PTPN22 and need of insulin for survival. In adults the same situation is often referred to as Latent Autoimmune Diabetes in Adults (LADA), with age at onset after 35 years and non-insulin requiring

Type 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. I have devoted the work presented in this thesis to attempt to elucidate the coupling of β-cell metabolism to insulin secretion and to look for casual mechanisms underlying metabolic alterations disturbing insulin secretion. In paper

Objectives: Celiac disease is a common immune mediated enteropathy strongly associated with HLA-DQB1*02 (DQ2), *0302 (DQ8), or both and the presence of tissue transglutaminase autoantibodies (tTGA). Prevalence studies have revealed that most affected individuals go undetected because of subclinical signs or being asymptomatic rendering screening a method for identification. However, less is known

Diabetes mellitus is one of the most common endocrine disorders in dogs and is commonly proposed to be of autoimmune origin. Although the clinical presentation of human type 1 diabetes (T1D) and canine diabetes are similar, the aetiologies may differ. The aim of this study was to investigate if autoimmune aetiology resembling human T1D is as prevalent in dogs as previously reported.

Sight-threatening diabetic retinopathy has been treated with photocoagulation for decades but the mechanisms behind the beneficial clinical effects are poorly understood. One target of irradiation and a potential player in this process is the retinal pigment epithelium (RPE). Here we establish an in vitro model for photocoagulation of human RPE cells.

It is crucial for social work education to provide opportunities for students to gain a sincere and genuine knowledge of the conditions of life that are common for their forthcoming clients and patients. Social work students and service users with experiences with multiple social and personal problems now meet, as they are participants in an experimental course at the School of Social Work in Lund

The object of this thesis has been to study the relationship between consumption and economic scarcity from a theoretical perspective. I have used families with children as an empirical example to illustrate the theoretical framework. There are two main questions: The first focuses on the structures that create specific conditions for low-income consumers. The second relates to how the households

In a middle-aged population, it was recently shown that the stable vasopressin marker plasma copeptin (copeptin) predicts development of diabetes mellitus, diabetic heart disease and death. Here, it was hypothesised whether copeptin predicts a risk of coronary artery disease (CAD), and cardiovascular mortality in an older population.

In a recent NJL article (Enger 2013), Hans-Olav Enger argues against some analyses of gender and ‘pancake sentences’, in particular against Josefsson (2009). In this short contribution, I will discuss what I take to be misunderstandings in Enger (2013). In addition I will discuss some data not included in Enger’s (2013) analysis, which I will show to be crucial for the comparison between the diffe

-Epigenetic alterations may contribute to the development of atherosclerosis. In particular, DNA methylation, a reversible and highly regulated DNA modification, could influence disease onset and progression since it functions as an effector for environmental influences, including diet and lifestyle, both of which are risk factors for cardiovascular diseases.