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Holocene recolonization and extinction of the pond turtle, Emys orbicularis (L., 1758), in Europe

We reconstruct the Holocene range fluctuations of the European pond turtle (Emys orbicularis) for northern and Central Europe. Based on 529 subfossil records and radiocarbon dating of critical finds, we provide evidence that E. orbicularis experienced a rapid range expansion with Holocene warming. Phylogeographic data argue for a colonization of northern and Central Europe from a glacial refuge lo

Cost-effectiveness of tacrolimus ointment vs. standard treatment in patients with moderate and severe atopic dermatitis: a health-economic model simulation based on a patient survey and clinical trial data.

Background Atopic dermatitis (AD) affects health and quality of life (QoL) and also has great impact on both healthcare costs and costs to society. Objectives The aim of the study was to analyse the cost-effectiveness of treatment with tacrolimus ointment vs. standard treatment in patients with moderate to severe AD. Methods A Markov simulation model was constructed capturing several key features