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Background: In luminal breast cancer, adjuvant CDK4/6 inhibitors (eg, abemaciclib) improve invasive disease-free survival. In patients with T1–2, grade 1–2 tumours, and one or two sentinel lymph node metastases, completion axillary lymph node dissection (cALND) is the only prognostic tool available that can reveal four or more nodal metastases (pN2–3), which is the only indication for adjuvant abe

The limited number of accurate and precise radiometric ages through the ~100 Myr span of the Cambrian and Ordovician impedes reliable age determinations for stage boundaries in these periods. Here, we fill significant gaps in the early Paleozoic chronostratigraphy by providing precise Re-Os time-pins. Sample selection is linked to a firm biostratigraphic framework built on the appearance and distr

The three short movements in “Aspects of Snow” are united by the theme of snowy landscapes depicted in the poems and also share concentrated musical material. The piece was written in 2012 and premiered the same year by the Malmö Academy of Music Chamber Choir under the direction of Mats Paulsson. Else Lasker-Schüler (1869–1945) was one of the leading German writers in the decades after the turn o

Att ersätta bilresor med cykelresor har många fördelar, både ur ett individ- och samhällsperspektiv, t.ex. bättre hälsa genom ökad fysisk aktivitet, lägre nivåer av föroreningar och trängsel. Det finns dock vissa potentiella problem med en sådan förändring. Cyklister löper exempelvis högre risk för trafikolyckor per fordonskilometer än bilförare. Denna risk måste minimeras för en optimal övergång A shift in modal share from car driving to cycling has many benefits, bothfrom individual- and societal perspectives, e.g., better health from anincrease in physical activity, lower levels of pollution and congestion.However, there are also some potential problems with such a shift. Cyclistshave a higher risk of traffic incidents per travelled kilometre than cardrivers. This risk needs to be minim

BACKGROUND: Women with intellectual disabilities face significant barriers to gynecological, reproductive, antenatal, and perinatal care, which may adversely impact maternal and fetal health. Previous research indicates increased risks for gestational diabetes, pre-eclampsia, caesarean birth, preterm birth, and other complications in pregnant women with intellectual disabilities. However, studies

Background: Acute aortic syndrome (AAS) is a life-threatening condition reported as often misdiagnosed. Advancements in CT availability and diagnostic algorithms, including high-sensitivity troponin and D-dimer for acute coronary syndrome (ACS) and pulmonary embolism (PE), may reduce AAS misdiagnosis, but the impact remains unclear. This study evaluated the incidence, characteristics, and clinical

Comparison of ROS production of individual particle components from traffic-related sources can inform new health policies and emissions legislation. This work aims to quantify acellular ROS production and oxidative potential (OP) of such individual particle components from combustion, brake, tire, and road wear. Particle characteristics are probed to identify source-specific markers and improve t

Importance Elevated blood pressure (BP) in adolescence has been linked to higher risk of cardiovascular disease mortality, as well as surrogate markers of atherosclerosis, such as carotid intima-media thickness and coronary artery calcification. However, these markers do not fully capture the complex spectrum of subclinical atherosclerotic cardiovascular disease. Objective To examine the associati

Elevated endostatin levels independently predicted 3-month mortality in acute dyspnoeapatients with CHF, but not 1-month mortality. Endostatin may aid intermediate-term risk stratification and warrants further validation.

Announced in this Comment and in collaboration with Nature Medicine is the convening of the Data-Driven Decision Support in Obesity Management Commission, to promote adequate scientific evidence to support obesity management across global populations.

Patienters behandlingspreferenser har under de senaste tre decennierna uppmärksammats som en potentiell moderator för behandlingsresultat. En dubbelrandomiserad forskningsdesign, ”Doubly Randomised Controlled Preference Trial” (DRCPT), där patienter randomiseras antingen till ett val mellan behandlingar eller till slumpmässig fördelning till en av behandlingarna, anses vara en av de mest lämpliga Patient preferences have drawn considerable attention as a potential moderator of treatment outcome. The Doubly Randomised Controlled Preference Trial (DRCPT) in which patients are randomised to a choice between two or more treatments or random assignment to one of these same treatments is considered one of the most rigorous tests of the effects of patient preferences on outcomes. To date, there h

Enkelt uttryckt är Samverkansinlärning (SI) en studiecirkel kopplat till en utmanande kurs. SI leds av en senior student som utformar läraktiviteter där studenterna arbetar i grupper med att förklara och förtydliga svårt kursmaterial. Målsättningen med SI, förutom förbättrade prestationer i den aktuella kursen, är att studenterna skall utveckla goda studiestrategier och bli mer självständiga i sit