Protein kinase C (PKC) is a serine/threonine kinase family with 10 identified isoforms. The contribution of PKC isoforms to cell growth and differentiation, with focus on neurite outgrowth, was investigated, using neuroblastoma and immortalised neural cells as model systems. In neuroblastoma cells one or several of the classical PKC isoforms are of importance for driving proliferation, protecting

This thesis covers 12 years of experience in treating patients with congenital capillary malformations, so called port wine stains (PWS). The wide variation in treatment response to laser therapy has developed a profound need for the development of objective devises to measure treatment outcome, so that the maximum effectiveness of therapy can be achieved without unnecessary treatments. The purpos

Abstract The electrophysiological properties of insulin-secreting b-cells, glucagon-releasing a-cells and somatostation-producing d-cells in intact mouse pancreatic islets were investigated using the perforated patch whole-cell technique. It is demonstrated that it is possible to functionally identify the different cell types in situ. The ?-cells have a cell capacitance of 7.4 pF and differ from

Life-threatening conditions from bacterial infections are a major clinical problem. During a severe infection, the host responds by a massive release of pro-inflammatory mediators together with a systemic activation of systems such as the coagulation, fibrinolytic, and complement systems. These events could result in the development of complications such as disseminated intravascular coagulation a

Molecular imprinting is a technique by which polymeric materials selective for a given target molecule can be created through a casting procedure. Functionalised monomers are added to a solution of molecular templates. Monomer-template complexes are formed and subsequently fixed through polymerisation, and following removal of the template species from the resultant molecularly imprinted polymer,

In the diet for young children, whole cow´s milk is the major contributor of calories, protein and saturated fat, but it supplies little iron and polyunsaturated fat. Although several recommendations exist for the composition of formula, recommendations for the composition of milk for young children are lacking. We investigated if milk with modified fat-, protein-, and iron content aimed at young

The purpose of the present thesis was to investigate Basic Body Awareness Therapy (Basic BAT) in psychiatric outpatient care and the BAS-H, an assessment method for analysing movements and movement behaviour. Important factors in the interaction, therapeutic relationship and working alliance between patient and physiotherapist (PT) were also explored. The results revealed the construct validity of

The aim was to compare radiography of the tibiofemoral joint (TFJ) and the patellofemoral joint (PFJ), as well as bone scinigraphy with MR imaging in middle-aged individuals with chronic knee pain in the format of a prospective study of knee osteoarthritis. Individuals aged 35-54 years with chronic knee pain were identified. The prevalence of chronic knee pain was 15% (279/2000). Within this grou

The main objective of this thesis was to investigate the fate of photoreceptor cells when using different strategies for retinal cell transplantation. Comparing transplantation of fragments of embryonic retina with cell suspensions of the same tissue we found that transplantation of fragments of embryonic retina result in mature transplants with a higher degree of cellular organization than transp

The parasympathetic nerves are important for the regulation of insulin secretion, in particular after meal intake. Apart from acetylcholine, several neuropeptides can be found in the parasympathetic nerves innervating the islets of Langerhans, including gastrin-releasing peptide (GRP) and pituitary adenylate cyclase activating polypeptide (PACAP). Exogenous administration of either GRP or PACAP ha

This thesis aims at reconstructing events in the solar system, mainly collisional events in the asteroid belt, by searches for extraterrestrial minerals in Paleogene and Middle Ordovician marine sediments on Earth. Recent empirical evidence show that Earth has experienced a few brief periods during the Phanerozoic when the flux of extraterrestrial matter significantly increased. The most prominent

Uppsatsen har sin utgångspunkt i det slutbetänkande 2014 års sexualbrottskommitté presenterade i oktober 2016. Fokus blir på de direktiv sexualbrottskommittén fick för att undersöka och ta fram ett förslag till en sexualbrottslagstiftning, som bygger på samtycke samt om och hur en oaktsamhetsbestämmelse skulle kunna utformas. Första delen av uppsatsen belyser lagstiftningsreformen från 2005, vilThe essay is based on the final report the 2014 Sexual Offences Committee presented in October 2016. Focus will be on those directives the 2014 Sexual Offences Committee was given in order to examine and develop a proposal to a sexual offence legislation built on consent and if and how a negligent regulation could be formed. The first part of the essay illustrates the legislative reform from the

Kroniska sjukdomar är den största orsaken till funktionsnedsättning och död, och även den största kostnaden för sjukvården. Ett sätt att minska trycket på sjukvården och samtidigt höja livskvalitén för patienter som lider av kroniska sjukdomar, är genom digitalisering av sjukvården. Regeringen har satt ett ambitiöst mål att Sverige ska vara världsledande inom e-hälsa år 2025. För att bidra till de

Representationskompetensen hos den verkställande direktören i svenska aktiebolag regleras genom 8 kap. 36 § ABL och därigenom rekvisitet ”löpande förvaltning” i 8 kap. 29 § ABL. Vad denna löpande förvaltning omfattar är dock inte helt tydligt och kan variera kraftigt mellan olika typer av bolag och situationer. Detta kan skapa såväl praktiska som juridiska problem för både bolag och den verkställa