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The thesis deals with models for molybdopterin-dependent enzymes. Several model systems containing molybdenum or tungsten have been prepared and characterised, and their reactivity with oxygen atom acceptors and donors have been investigated. Oxygen atom transfer reactions involving oxomolybdenum bis-dithiolene complexes have been modelled using density functional calculations. The first molybden
Neuroblastoma is a pediatric tumor derived from cells in the sympathetic nervous system. In an attempt to explain the heterogeneous clinical behavior of neuroblastoma tumors, neuroblastomas have been characterized with regard to their degree of sympathetic differentiation. Their expression of genes and proteins that regulate normal sympathetic development and cell cycle/cell death regulators was a
The studies in this doctoral thesis investigated how home literacy, self regulation, academic self-concept, and goal orientation influence reading ability. Study 1 investigated the effect of family-based prerequisites, reading attitude, and self-regulated learning on reading ability. Students (n= 4,018) in the eighth grade answered the IEA reading literacy test and the SRLQ. Structural Equation Mo
The ABO blood group system is undoubtedly the most important genetic and phenotypic marker in clinical transfusion medicine. The A and B determinants are immunodominant, terminally located carbohydrate residues of glycoconjugates on erythrocytes and other cell surfaces. The enzymes responsible for assembly of these structures are glycosyltransferases encoded by the ABO genes on chromosome nine. T
C4b-binding protein (C4BP) is an acute-phase plasma glycoprotein which regulates the complement system through its affinity for C4b. In addition, C4BP binds to the anticoagulant protein S and to serum amyloid P component (SAP). Protein S is a vitamin K-dependent protein which looses its anticoagulant properties when binding to C4BP. C4BP is composed of two types of subunits, the a-chain and the b-
Leukemic cells suffer from an impaired ability to differentiate due to inherited or acquired genetic lesions. These genetic changes can sometimes be bypassed with various compounds both in vitro, and, more rarely, in vivo, thus inducing terminal differentiation of the leukemic cells. Differentiation of both leukemic and normal hematopoietic cells is believed to be intimately coupled to cell cycle
Purpose – In the recent redefinition of the European Commission's corporate social responsibility (CSR) strategy, attention is brought to CSR as a motor for innovation. However, literature in the area remains scarce. This chapter describes and discusses innovation as a consequence of a firm's CSR activities. Methodology/approach – The empirical part of the chapter is based on the content analysis
The neutrophil granulocyte contains a number of multifunctional proteins stored in different subsets of granules. The azurophil granules, synthesized early during differentiation, harbour leukocyte elastase, cathepsin G, proteinase 3, and azurocidin; the members of the serprocidin family. In order to study the biosynthesis, processing, and intracellular sorting of the proteins, human cDNA encoding
This thesis explores in-group bias control. It is well-known that people tend to have extra liking for people they identify themselves with. An extra positive in-group attitude may cause discrimination, even in the absence of any negative attitudes towards the out-group. At the same time are many people motivated to behave and present themselves as unbiased. We study whether people attempt to cont
A new approach to the study of aqueous mixtures of oppositely charged polymers and surfactants has been introduced. Pure polyion-surfactant ion complex salts have been synthesized and used as the point of departure. The elimination of the simple ions reduces the number of components in the mixtures, thus greatly simplifying the system. By mixing the complex salt with either the polyelectrolyte or
