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Objective: To examine adherence to the oral glucose tolerance test (OGTT) in multiple islet autoantibody children in stage 1 of developing type 1 diabetes (T1D). Methods: Children are followed from birth in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Completion of an OGTT is recommended every 6 months in children ≥3 years of age who are multiple islet autoantibody positi

Patienters behandlingspreferenser har under de senaste tre decennierna uppmärksammats som en potentiell moderator för behandlingsresultat. En dubbelrandomiserad forskningsdesign, ”Doubly Randomised Controlled Preference Trial” (DRCPT), där patienter randomiseras antingen till ett val mellan behandlingar eller till slumpmässig fördelning till en av behandlingarna, anses vara en av de mest lämpliga Patient preferences have drawn considerable attention as a potential moderator of treatment outcome. The Doubly Randomised Controlled Preference Trial (DRCPT) in which patients are randomised to a choice between two or more treatments or random assignment to one of these same treatments is considered one of the most rigorous tests of the effects of patient preferences on outcomes. To date, there h

BACKGROUND: Bile duct injury (BDI) is a severe complication following cholecystectomy. Early recognition and treatment of BDI has been shown to reduce costs and improve patients' quality of life. The aim of this study was to assess the effect and cost-effectiveness of routine versus selective intraoperative cholangiography (IOC) in cholecystectomy. METHODS: A systematic review and meta-analysis, c

Aims: A diabetic foot ulcer (DFU) is associated with increased cardiovascular risk and mortality, independently of ulcer etiology (ischemic, neuro-ischemic or neuropathic). Ankle–brachial index (ABI) is the most commonly used test when diagnosing peripheral macrovascular disease and is a well-known marker for increased cardiovascular risk. Transcutaneous oxygen pressure (TcPO2) is considered to be

Objective: Monoclonal gammopathy of undetermined significance (MGUS) is the asymptomatic precursor of multiple myeloma (MM). Lytic bone lesions and fractures are hallmarks of MM and although there are no lytic lesions in MGUS, it has also been associated with fractures. The causes of fractures in MGUS are currently unclear but potential causes include inherent MGUS bone disease, undiagnosed MM, an

INTRODUCTION The closure of a local labor ward enhanced the possibility to initiate a continuity of midwifery care model project. Continuity models of midwifery care are a cornerstone in midwifery and women-centered care, mainly accessible in metropolitan areas. Australian studies have found continuity of midwifery care to work well in rural areas. The aim of this study is to describe midwives’ ex

Background: Preeclampsia (PE) is a “multifactorial syndrome” in which ambient air pollution may contribute to the etiology of PE. However, the underlying mechanism of this association is not clearly elucidated. This dissertation aims at understanding the placental molecular mechanism underlying the relationship of prenatal exposure to ambient air pollution with preeclampsia and fetal growth by cha