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A new method, where a tendon segment – a tendon autograft – was used as graft material for peripheral nerve reconstruction, was developed. Defects, 10-15 mm long, in rat sciatic nerves were bridged by various modifications of tendons. A piece of an intact tendon and a tendon, that had been teased into a membrane and then rolled to form a loose “collagen roll”, supported axonal regeneration over a
Purified bacterial cell wall components peptidoglycan and teichoic acid were isolated from staphylococcal species S. aureus and/or S. epidermidis and tested for their ability to induce cytokine release from plastic-adherent human monocytes. Both cell wall components dose-dependently induced TNF-alpha, interleukin-1beta, and interleukin-6 release, peptidoglycan being more potent than teichoic acid.
The aim of this study was to evaluate MRI with contrast enhanced MR angiography (MRI/CE MRA) as imaging method before and after endovascular repair of abdominal aortic aneurysms (AAA). A 1.5 T scanner was used for all examinations. In this prospective study 26 consecutive patients were included. Follow-up was performed between February 1995 and May 2002 (median follow-up; 36 months, range 8-84 mon
The pro-inflammatory mediator, Leukotriene D4 (LTD4) is a product of arachidonic acid cascade and has been implicated in asthma and inflammatory bowel diseases. Prolonged inflammatory conditions like ulcerative colitis increases the risk for the development of cancer and the factors that induce the chronic immune response remain uncertain. In this context, in the present study, we examined if expo
Transportation fuels from renewable resources such as ethanol are one of the alternatives to ensure energy security and decrease the net emission of carbon dioxide. First-generation ethanol production from sugar- and starch-based raw materials (1G) is today well established in many countries, and the focus of research has thus shifted to the development and demonstration of the production of secon
The efficacy of surgery, physiotherapy or a cervical collar in the treatment of chronic cervicobrachial pain of radicular origin was evaluated in a prospective, randomised study comprising 81 patients of both sexes, 28-64 years of age, referred for possible neurosurgical treatment. After neurological and radiological examination and giving their informed consent, they were randomised to one of the
The varieties of prey phenotypes that have been revealed in nature are vast and many of these phenotypes are the result of the selective force that predators have had on prey traits in the past. Even within species and populations we see variations due to both differences in the selection forces they live under but also due to individual trait variation. In this thesis I investigate both the direc
Aggressive lymphoma is a rapidly growing tumour of lymphocyte origin, potentially curable with chemotherapy. In a trial by the Nordic Lymphoma Group, 405 patients with aggressive lymphoma were included, and randomised to receive either the standard chemotherapy regimen, CHOP, or a weekly multidrug regimen, MACOP-B. In this trial, MACOP-B was not superior in terms of response, failure-free or overa
The process of speciation is a cornerstone in evolutionary biology. In Darwin’s On the Origin of Species, he described how he imagined that a new species would evolve to fill an empty niche. This focus on ecology shifted with Mayr towards the importance of isolation, and for many decades the geographic modes of speciation were debated. Speciation in sympatry, i.e. without any isolation between the
The importance of early detection of brain changes during ageing has been recognised. Single photon emission computed tomography (SPECT) is a method used for estimation of cerebral blood flow (CBF) in clinical work and in research. The aim of thesis was to study CBF in demented and non-demented elderly persons with special reference to blood pressure changes. Elderly women with senile dementia of
For a long time microorganisms were assumed to have unlimited dispersal due to their small size and high cell numbers. Most microbial species can be transported by water currents, in water droplets by wind and attached to other organisms. Environmental conditions alone were supposed to affect the distribution of species and the community composition. Therefore, microorganisms were assumed to consi
Urinary tract infections (UTI) are among the most common human infections, and febrile UTI with bacteremia the most severe form. The relation between bacteria and host decides disease severity. The dominating uropathogen is Escherichia coli (E. coli). P fimbriae are the virulence factor of E. coli most clearly associated to severe disease. P fimbriated E. coli predominated in bacteremic febrile UT
Leukemic cells suffer from an impaired ability to differentiate due to inherited or acquired genetic lesions. These genetic changes can sometimes be bypassed with various compounds both in vitro, and, more rarely, in vivo, thus inducing terminal differentiation of the leukemic cells. Differentiation of both leukemic and normal hematopoietic cells is believed to be intimately coupled to cell cycle
The general objective of the research underlying this dissertation was to conduct clinical and basic scientific studies to further elucidate the hemophilia and the coagulation process, with the goal of improving the care of families with these disorders. More specific aims were to evaluate epidemiological, genetic, clinical, and biochemical aspects of the development of inhibitors (antibodies) aga
