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Acquired genetic alterations, of which many are visible on the chromosome level, are believed to be necessary for tumorigenesis, and most tumors display characteristic patterns of recurrent structural and numerical aberrations. However, two of the most frequently occurring chromosome mutations in malignant and benign solid tumors, i.e., trisomy 7 and rearrangements of 12q13-15, have recently been

Purpose: Supply chain efficiency (economic and ecological) is affected by packaging design. The purpose of this research is to investigate how integrated approaches aiming for ecoefficient supply chains are used in packaging development processes and how a set of preselected factors influences the adaption of more or less integrated approaches at companies. Design/methodology/approach: The researc

Many bacteria express immunoglobulin(Ig)-binding proteins that interact with Ig in a non-immune manner. Several of these Ig-binding bacterial proteins have been well characterized and are widely used as reagents for analysis and purification of Ig's. Protein G found on group C and G streptococci has affinity for constant regions of IgG heavy chains, whereas protein L found on Peptostreptococcus ma

The Wnt-5a gene encodes a secreted protein that regulates several normal processes in embryonic and adult tissues by as yet unknown mechanisms. Expression of Wnt-5a protein does not cause cell transformation, but it instead counteracts the effects induced by transforming Wnts. Inasmuch as Wnt-5a can activate the Wnt/beta-catenin signalling pathway, we performed experiments to determine whether mol

This chapter will look at why, how and in what way a spontaneous memorial may develop: from an immediate act to a more planned place of grief and remembrance (Clark and Franzmann 2006, Nieminen Kristofersson 2006, Klaasens, Groote and Huigen 2009). Of special importance for this investigation are the noticeable differences in attitudes to and growths of roadside memorials revealed by data gleaned

The purpose was to describe ethical aspects on how do-not-resuscitate (DNR) deci-sions are made, established, and communicated between physicians, nurses, patients and relatives. A random sample of 220 physicians and nurses answered a questionnaire about their attitudes to and experiences of the making and communication of a DNR decision. The re-sponse rate was 73%. Twenty seriously ill patients,

Reductions in ambient pressure liberates gas in various tissues and can result in decompression illness. In this thesis the patophysiological implications of a blood gas interface resulting from decompression was investigated with reference to the influence on biochemical mediators of inflammation. In a series of experiments, animals and human subjects have been exposed to hyperbaric trauma of dif

Pathogen challenges and host immune defenses can have substantial impact on life history patterns of animals. Biotic and abiotic factors may affect immunity in wild animals, influencing e.g., population dynamics and sexual selection. The overall aim of this thesis was to assess costs and benefits of immune system activation on physiology, behavior and offspring phenotype. The conducted research ha