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Abstract Title: How to source from Russia? - A multiple case study of six companies’ experience of purchasing in Russia. Authors: Richard Werthén, Technology Management Johan Öhlén, Production Engineering and Management Supervisors: Christer Kedström, Dept of Business Administration Johan Lundin, Dept of Industrial Management and Logistics, Engineering Logistics Rolf Blomgren, Purchasing Manager S

The incidence of diabetes is increasing worldwide, with the most prevalent form being type 2 diabetes. Two fundamental processes contribute to the development of type 2 diabetes: insulin resistance in target organs and insufficient insulin secretion from the pancreatic beta-cells. The aim of this thesis was to explore the role of DNA methylation and common genetic variation on glucose metabolism a

Klimatet har varit relativt stabilt under den nuvarande interglaciala epoken (Holocen) som inleddes för ungefär 11 700 år sedan. Genom klimatrekonstruktioner från olika geologiska arkiv såsom iskärnor, sjösediment och torvmossar har det ändå påvisats att snabba förändringar i klimatet har inträffat under denna epok. En sådan tidsperiod inträffade för omkring 2800 år sedan och den är intressant ur Geological archives have shown periods of abrupt climate change in the relatively stable Holocene epoch (last ca. 11 700 years). One of these periods was around 2800 cal BP. Several records, mainly from Europe, reveal a shift towards wetter, cooler and windier conditions. There are, however, indications for a global extent of the climate change. The climate change coincides with a distinct increas

Atherosclerosis is a chronic inflammatory disease characterized by the formation of lipid rich plaques in the arterial wall. Rupture of a plaque results in clinical manifestations such myocardial infarction or stroke. Atherosclerosis is a complex disease where both autoimmune responses towards atherosclerosis-related antigens and smooth muscle repair responses play important roles. This thesis con

One of the great challenges in breast cancer treatment today is to customize adjuvant treatment to each patient’s individual needs. To do this it is necessary to learn more about the prognostic and treatment predictive factors that determine the risk of relapse and response to a certain mode of treatment. This thesis describes studies on the effect of amplified in breast cancer 1 (AIB1), a coactiv

Detta är en historiografisk studie av hur några välkända svenska historiker har använt sig av de isländska sagorna när de presenterat perioden som vi idag kallas vikingatid. Vikingatiden har haft en viktig funktion i konstruktioner av kollektiva identiteter, och i sökandet efter relevanta förfäder, vilket passar bra ur ett historiekulturellt perspektiv.När medicinprofessorn Olof Rudbeck skrev sitt

The principal aim of the thesis is to evaluate the significance of the documentation of a building’s history for the work of restoring it and caring for it. Thus it may be said to address restoration as a hermeneutical problem, besides considering the relationships between the work of documentation; analyses of the resulting data; and the creative process in which the ideology of restoration is im

There are many contributing factors to the development of type 2 diabetes, however, failure of beta-cells to sufficiently secrete insulin is the key component. The underlying mechanism of beta-cell failure is not fully established. In this thesis, we examined the role of high glucagon levels, i.e. hyperglucagonemia, for the development of beta-cell dysfunction in pre-diabetic mice. We found that i

The Fountain House Movement – or the Clubhouse Movement - is an organization for community support, meeting the needs of adults suffering from mental illness. It was founded by a self-help group among discharged patients in New York in the 1940s. Today there are more than 300 clubhouses around the world. The aim of this dissertation is to characterize, interpret and understand the Clubhouse Moveme

Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). The aim of this thesis has been to investigate functional and genetic events that

Polycyclic aromatic hydrocarbons (PAHs) are a group of organic pollutants of great environmental concern, due to their toxicity, carcinogenicity and long persistence in the environment. To determine the potential risk associated with PAHs released from contaminated soil or waste materials, knowledge is required on the leachable concentrations of PAHs and the amounts available for release. The obj

Leisure Activities in Rheumatoid Arthritis. Associated Factors and Assessment. Leisure activities were considered to give intrinsic pleasure, meaning and value to life already in ancient Greek. It was also performed for its own sake and not by consideration of any external rewards. In the beginning of the 20th century leisure was only possible for wealthy people who could occupy themselves with n

I de flesta av EU:s medlemsstater kan bolag inom samma koncern resultatutjämna mellan sig. Förutsatt att bolagen har hemvist i samma medlemsstat kan ett bolag som går med vinst utjämna denna mot ett annat koncernbolags förluster. På så vis blir koncernen beskattad för sitt nettoresultat och skattebelastningen blir varken högre eller lägre än om verksamheten hade bedrivits inom ett enda bolag istälMost EU Member States have tax systems allowing domestic groups of companies to offset their losses both horizontally and vertically within the group. Since the groups will be taxed on their net result, the overall tax burden is neither higher nor lower than if carried out within a single company. If, however, the group chooses to establish a company in another Member State, it looses the right t