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Type 1 diabetes is one of the most common chronic diseases in childhood and adolescence with an increasing incidence worldwide. It is an autoimmune disease with many autoimmune markers, where the zinc transporter 8 autoantibody (ZnT8A) is the most recent autoantibody discovered. The most important genetic susceptibility towards type 1 diabetes is found within the HLA-region on chromosome 6. We sho
Every day we encounter many potentially harmful microbes in our environment. The epithelial linings constitute an anatomical barrier protecting us and they also produce antimicrobial polypeptides (AMPs) that act as a chemical barrier. These AMPs are small and positively charged, killing a broad range of microbes rapidly. They can either be constitutively produced or rapidly induced when epithelial
Background: Pancreatic cancer is the fourth leading cause of cancer-related death. Only about 6% of patients are alive 5 years after diagnosis. One reason for this low survival rate is that most patients are diagnosed at a late stage, when the tumor has spread to surrounding tissues or distant organs. Less than 20% of cases are diagnosed at an early stage that allows them to undergo potentially cu
Introduction: The mechanism of post ischemic reactive hyperemia is still unknown but now thought to be multifactorial and perhaps involving purinergic signalling. Purines such as ATP and ADP have recently been discovered to play a vital role in the regulation of vascular tone. We postulated that ADP could play a vital role in the mechanism of coronary post ischemic reactive hyperemia and that incr
Human epidermal growth factor receptor 2 (HER2) is overexpressed and/or amplified in 15-20% of all breast cancers, and is associated with an aggressive tumour type with impaired prognosis and a predictive marker for trastuzumab treatment. HER2 status can be determined by immunohistochemistry (IHC) at protein level and by fluorescence in situ hybridisation (FISH) analysing gene amplification, and i
Transplantation of embryonic dopaminergic neurones can ameliorate symptoms in Parkinson’s disease, but a major obstacle for clinical transplantations to overcome is the low survival (typically 5-10%) of implanted nigral neurones. If cell death in nigral grafts can be prevented, less embryonic tissue would be needed per transplantation session and hence more patients could receive intracerebral gra
The foraging ability of an organism is essential since it affects various traits, e.g. growth, reproduction effort, social status and, ultimately, fitness. Foraging is often associated with food intake but includes more aspects such as searching for and assessing food patches and evaluating the patch as good or bad compared to the rest of the environment. On top of that, a forager also has to surv
Mucins are essential components of the mucosal barrier. The complexity of the airway mucosal barrier is reflected in the lack of specific treatments to block mucin hypersecretion associated with several respiratory diseases such as chronic bronchitis, asthma and cystic fibrosis. Currently, researchers in the mucin field are confronted with a growing number of mucin genes. In order to understand th
Type-2 diabetes is characterized by impaired insulin secretion associated with excess glucagon release. Exocytosis of insulin- or glucagon-containing granules is initiated by Ca2+-influx through voltage-dependent Ca2+-channels and is modulated by the second messengers such as cAMP. Membrane capacitance measurements were used in this study to investigate the cellular mechanisms behind cAMP-regulate
For more than a century, an immense interest has been devoted to the study of recognition memory, where a multitude of memory phenomena has been explained. Recognition memory is usually described with parsimonious measurement and statistical models, stemming from dual process theory and signal detection theory. In the present thesis, the most often used models of recognition memory are reviewed an
Filmpolitiken står inför sin största förändring på över femtio år: filmavtalet som präglat filmens stödsystem sedan 1963 ska från den 1 januari 2017 ersättas med en ny helstatlig filmpolitik. Beslutet grundar sig på att filmbranschen har uttryckt missnöje med hur avtalet fungerar i ett filmlandskap och samhälle, som ser så annorlunda ut mot när avtalet infördes. Uppsägandet innebär en stor omstruk
