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Mutation rates for X-linked recessive diseases have so far been estimated indirectly by postulating an equilibrium between the loss of defective genes caused by the low reproductive fitness of affected males and the gain resulting from new mutations. Here, for the first time, we directly estimate both the overall and sex-specific mutation rates for haemophilia B by detecting the gene defect of the
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In North Sámi, verbs that form transitivity alternation pairs are always distinguished morphologically. However, even if morphology is seen as a reflex of the syntax, the syntactic structure underlying transitive and intransitive verbs in North Sámi cannot be directly read off from the morphology. Since the verbalisers have vocalic phonological realisations with some roots but consonantal realisat