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STUDY OBJECTIVES: To calculate incremental cost-utility ratios (cost per QALY gained) for varenicline (Champix; Pfizer), as compared to bupropion, in smoking-cessation programmes for a lifetime follow-up period. DESIGN: The Benefits of Smoking Cessation on Outcomes (BENESCO) simulation model was used for a male and female cohort, respectively, as a point of departure but further extended in order

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To evaluate how inbreeding affects the viability of small populations, it is crucial to determine what constitutes a population (i.e., the number of breeders in local patches and the degree of dispersal), and also to estimate the reproductive consequences of philopatry and emigration. In this thesis, I concentrate on dispersal, inbreeding and fitness in natural populations. I consider dispersal ra

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A decline of suicide rate can be accomplished by different psychiatric interventions. Early identification of individuals at risk for future suicide is especially important. Results from rating scales could add detailed information, which in turn might strengthen a psychiatric suicid risk assessment. This thesis deals with emergency evaluations and psychiatric inpatient evaluations after a suicide

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Although memory often serves us well, it can also prove highly unreliable. The study of illusions and distortions of memory unveils important information about the nature of human memory functioning and, moreover, factors affecting memory accuracy. By taking a cognitive neuroscience perspective, the present dissertation aimed at elucidating processes promoting both true and false remembering and t

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The importance of studying cardiovascular disease before the process leads to hard end-points has been recognised, and methods to quantify early atherosclerosis have been taken in use in many research centres around the world. An ultrasound method with a computer assisted image analysing system was developed in co-operation with the Wallenberg Laboratory for Cardiovascular Research and Chalmers Un