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There are many contributing factors to the development of type 2 diabetes, however, failure of beta-cells to sufficiently secrete insulin is the key component. The underlying mechanism of beta-cell failure is not fully established. In this thesis, we examined the role of high glucagon levels, i.e. hyperglucagonemia, for the development of beta-cell dysfunction in pre-diabetic mice. We found that i

There is currently a dramatic and global increase in obesity, type 2 diabetes (T2D) and associated metabolic disorders. T2D can be delayed or prevented in individuals at risk and identifying and developing new food concepts for the prevention of obesity and T2D is of utmost importance. This thesis describes our work on exploring new food concepts for the prevention of T2D. We have used 3T3-L1 adip

Palaeomagnetic studies of continuous geological archives and archaeological artefacts are required to reconstruct geomagnetic field changes beyond the range of historical observations. In this thesis I assess the reliability of sedimentary palaeomagnetic data and Holocene dipole field reconstructions. New palaeomagnetic records are presented from a maar crater lake in New Zealand and a post-glacia

The overall aim of this thesis was to estimate health economic consequences of the four-month primary care program ”Physical Activity on Prescription (PAP)”. Inactivity means a highly increased independent risk factor for public health diseases and morbidity, and is an economic burden to society. Evidence for cost effective interventions aiming at increasing physical activity (PA) level among inac

Defective insulin secretion and insulin resistance are the two hallmarks of Type 2 Diabetes (T2D). The pathophysiology of the disease is not fully understood but genetic susceptibility for the disease is a new major player in the understanding of the underlying mechanisms. T2D research has in recent years invested tremendous efforts in identifying new risk variants for the disease. It has proven t

The hepatitis C virus (HCV) is a blood borne virus effectively spread through injection practices. Consequently, people who inject drugs (PWID) are at the center of the current HCV epidemic in industrialized countries, with regards both to prevalence and incidence. Through progressive liver fibrosis, chronic HCV infection conveys a substantial risk of liver cirrhosis and end-stage liver disease. T

The sexuality of hivinfected people is quite controversial but nevertheless important when speaking of hivprevention. The aim of this work was to survey and analyze support and counseling practices around sexual issues given to hivpositive people by their treating medical doctors. We wanted to bring the question of hivinfected peoples sexuality and sexual behavior sometimes unprotected and the Swe