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Helicobacter pylori is a gastric pathogen which cause chronic type B gastritis and peptic ulcer disease. H. pylori produces virulence factors such as urease, vacuolating cytotoxin VacA, cag pathogenicity island-associated proteins, flagella and adhesins. These proteins interact with several host cell molecules such as sialylated cell surface glycoproteins, some of glycolipids and mucins. Glycosami

Artificial, amfiphilic, and biomimetic receptors soluble in water were synthesized via attaching polar amino acids to hydrophobic back-bones possessing a surface suitable for hydrophobic interactions. The hydrophobic back-bones chosen in this thesis were anthracene and dibenzobarrelene structures. A route to an efficient synthesis of a dibenzobarrelene backbone with two sets of orthogonal reactivi

In fantasy literature, the setting is as important to the story as are characters and plot; but although many fantasy scholars have pointed this out, there is very little criticism that explores the role of the setting in fantasy. The aim of this study is to use a topofocal (place-focused) perspective to examine four aspects of the fantasy setting, including the way in which settings function in t

In this thesis, electron transport in mesoscopic semiconductor nanostructures, in particular so-called electron billiards or quantum dots, is studied. The thesis can be divided into two areas: the linear response regime of transport, and the nonlinear response regime of transport. The classical and quantum mechanical electron dynamics are studied for triangular and square-shaped electron billiard

This study is based on dialogic readings of two of John Cowper Powys´s major novels, A Glastonbury Romance and Porius. The aim of this thesis is to demonstrate the interrelationship in the examined texts between the chain of narrative displacements and the frequent changes of voice and genre. Powys´s cornucopian writing with its wide employment of characteristics from various genres

The root vole (Microtus oeconomus) is a rodent with Holarctic distribution. In fact, it is the only Microtus vole found in both Eurasia and North America. Phylogeographic analyses of the root vole from across its distribution range were performed using mitochondrial and Y chromosome DNA sequences. Mitochondrial cytochrome b gene data demonstrate that the root vole is divided i

Phage display technology is a biotechnological tool that can be used to obtain molecules/reagents able to discriminate between target molecules. Reagents with such features can be used in diverse settings like biological chemistry, diagnostics and in therapeutic applications. Phage display technology is based on the use of recombinant DNA technology, bacteria and a special kind of bacterial virus,

The regulation of the exocrine pancreas has been under thorough investigation for many decades. In rats, cholecystokinin (CCK) is considered to be the major gut hormone stimulating the pancreas to releasing the digestive enzymes. CCK acts directly via CCK-A receptors in the pancreas, or through receptors located on the vagal afferents and stimulating the secretion via the cholinergic vagal efferen

Temporal lobe epilepsy (TLE) is the most common form of epilepsy among adult patients, and the most problematic one as seizures cannot be controlled by currently available drugs in 30 % of patients. Gene therapy based on overexpression of endogenous anti-epileptic agents such as the neuropeptide galanin and the glial cell line-derived neurotrophic factor (GDNF) represents a promising new approach

One of the most important aspects of the marriage legislation in medieval canon law is the doctrine of free choice. According to this doctrine, established by pope Alexander III in the second half of the twelfth century, the validity of a marriage depended solely on the freely given consent of the parties. Neither family nor witnesses, not even the presence of a priest were necessary to form a val

In this thesis the role of cartilage proteins and their potential as antigen and availability to the immune system in arthritis were investigated. Six papers are included; where four present new animal models for Rheumatoid arthritis (RA), one shows how genetic disorders in cartilage may affect arthritis and the last how posttranslational modification of collagen type II (CII) affects tolerance. P

The main contribution of this thesis is approximation algorithms for several computational geometry problems. The underlying structure for most of the problems studied is a geometric network. A geometric network is, in its abstract form, a set of vertices, pairwise connected with an edge, such that the weight of this connecting edge is the Euclidean distance between the pair of points connected. S

This study challenges the prevailing assumption that the expansion of cultivated land areas and increasing number of livestock in the agro-pastoral regions of northern China have aggravated the process of land degradation since the start of the rural reforms in 1978. Land-use and productivity trends in the Inner Mongolia Autonomous Region (IMAR), with special attention to the Keerqin steppe region

This thesis discusses the religious metaphorical use of different words for "shield" in the Hebrew Bible and Egyptian and Assyrian literature. The literary contexts in the analysis are delimited based on the observation that they share a similar view of divine intervention in war and an analogous view of the enemy. Using the defensive weapon that we today call the "shield" often meant the differen

Physician and patient do not meet as equals in the consultation. It is the responsibility of the physician to actively work for better communication in order to provide equitable health care for all individuals. Immigrant patients are a vulnerable group, shown in studies all over the world to have less access to care, fewer opportunities for health, and poorer health compared to majority populatio

Cardiovascular disease (CVD) is characterized by lipid accumulation and inflammation in arteries. The disease starts early in life with migration of monocytes into the arterial wall where they engulf entrapped lipoproteins and become macrophage foam cell. A simultaneous inflammatory response further enhances lipid and cell accumulation at sites of lesion development, resulting in progression of at

The motivation to study the kind of problems appearing in this thesis has been ultrasound measurements of flows, from which velocity spectra along lines can be determined. These velocity spectra can mathematically be described by a new non-linear transform, here called the Doppler Spectral Transform (DST). The Doppler spectral transform has a very rich theory, into which some steps are taken here

Modern dead-ice environments in the glacier forefields of Brúarjökull, Iceland and Holmströmbreen, Svalbard were investigated with focus on landform and sediment genesis, as well as quantification of melting. Field monitoring and studies of multi-temporal aerial photographs, satellite imagery, and Digital Elevation Models (DEMs) provided data for the melting quantification. Sedimentological and ge

Rainfall characteristics of Kuala Lumpur, Malaysia, are studied in space and time; on a large scale, 550 km2, and long term scale to find out the monsoon influence, and on urban basin scale, 23 km2, to determine dynamic properties of rainfalls and spatial correlations, and on a point scale to determine the probabilities of very high rain intensities. The importance of spatial and temporal variabi