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Mature blood cells are crucial for life, but they have a short lifetime and thus have to be replaced. These mature blood cells are produced by lineage restricted progenitors, which themselves are generated by rare multipotent hematopoietic stem cells (HSCs) in a highly dynamic process called hematopoiesis. In addition to the ability of HSCs to generate all blood cell lineages, they possess the uni
A highly dealuminated form of zeolite FAU, ultra-stable zeolite Y (USY), was used as an adsorbent matrix in the purification of proteins. Undesired proteins were removed from a crude preparation by adsorption on USY, increasing the purity of an unadsorbed protein (horse radish peroxidase), or the protein of interest was adsorbed on the zeolite and subsequently eluted through changes in the solutio
Specific language impairment (SLI) is commonly described as a condition where a child with otherwise normal development and hearing does not acquire language as expected. Children with SLI often have a family history of language disorders. The aetiology is poorly understood. In the first two studies, event-related brain potentials(ERPs)evoked in response to tone- and to speech stimuli were record
Proton nuclear magnetic resonance (NMR) was used to study the self-diffusion of water in porous systems that respond to a change in water content in order to elucidate the porous structure and the properties of the confined water. In the carbohydrate systems cellulose fibers and starch granules, water is free to move throughout the porous objects, albeit with a rate reduced from the value of the
Evaluation of long-term side effects of treatment is important due to the growing number of childhood cancer survivors. How kidney function is affected over time needs to be clarified. In the first article, we investigated 247 healthy infants and children and established upper reference limits for several proteins in urine, to be used as markers for glomerular and tubular proteinuria in children w
The overall aim of this thesis was to increase our knowledge of the relationship between structure and function of human skeletal muscle, and about factors affecting strength. The ankle dorsiflexor muscles (DF) were chosen as a representative model of human skeletal muscle, and because these muscles have important roles in gait and maintenance of balance. Specific aims in this thesis were: i) to d
It is attractive to integrate a large deformable mirror for adaptive optics into an astronomical telescope rather than using relay optics within an auxiliary instrument. However, the resulting large deformable mirror can be expensive, particularly for extremely large telescopes. We have pursued a low-cost approach using force actuators connected to the back of the deformable mirror through suction
Transplantation is the only cure for end-stage organ failure. With the transplantation follows the need for continuous treatment with immunosuppressive agents for as long as the graft functions, which entails major side effects. Less toxic treatments are therefore in great demand. Preferably, the treatment should also be limited in time. The ultimate solution would be induction of tolerance to t
Our research group has previously shown that treatment with the polyamine biosynthesis inhibitors a-difluoromethylornithine (DFMO) or amidinoindan-1-one 2´-amidinohydrazone (CGP 48664) inhibited S phase progression before any other cell cycle phase was affected. This study was undertaken to further investigate the role of polyamines in the regulation of S phase progression and DNA synthesis. I hav
Schizophrenia is now generally considered to be a brain disease resulting from disturbed neurodevelopment, mediated by genetic and/or adverse events in utero and/or in early childhood. This process manifests itself in schizophrenia in young adulthood, when the brain completes its maturation. The background and development of affective psychosis have been less extensively investigated. Our aim was
Birds use vision to guide navigation, foraging and mate choice, and studies of the limitations in bird visual perception are most helpful for the understanding of bird ecology. Here, I present four studies of bird vision in bright and dim light. Paper I is a quantification of how sensitive colour vision modelling is to variation in data, such as the spectral sensitivity of photoreceptors and recep
In a retrospective follow-up study, n=202, long-term pain relief (>6 months) after a course of acupuncture treatments was found mainly among patients with chronic nociceptive pain while patients with neurogenic or psychogenic pain did not benefit much. In a placebo-controlled randomised single-blind long-term study with independent observer of chronic nociceptive low back pain, n=50, it was found
The objective of the work described in this thesis is to identify the principles and parts of an aftertreatment system for the catalytic NOx reduction for heavy-duty diesel vehicles, and to demonstrate such a system in full-scale. The reducing agent is diesel fuel. Many advantageous features of the diesel engine, such as life span, reliability and efficiency, make the engine the most frequent pow
Extant research within the entrepreneurial marketing field has typically focused on the migration away from traditional marketing concepts while mostly ignoring the inclusion of branding as a fundamental principle of marketing. This paper is specifically interested in the often overlooked element of a young firm’s ability (or lack thereof) to control its brand and brand identity as perceived by it
Introduction: Dental caries among preschool children is a global problem, a burden on children’s well-being, and an economic burden on healthcare systems. In Sweden, preschool children with an immigrant background have a higher prevalence of caries. Extensive treatment need and long-standing poor oral health may require dental treatment within hospital care. This study aimed to investigate whether
My identity in the eyes of myself and others [translated title]. The purpose of this study was to examine how teenage girls experience their identities and how it is constructed and influenced by external factors. It was also an attempt to illustrate how mass media and social media like Facebook and blogs can be elements in the construction of identities. Berger and Luckmann‟s social construction
Popular science Biogenic volatile organic compounds (BVOCs) are a versatile group of non-methane hydrocarbons (chemical compounds made of carbon and hydrogen) emitted by vegetation. The most common BVOCs from plants are some chemical compounds like isoprene, monoterpenes and sesquiterpenes. BVOCs are involved in plant growth, reproduction and defense mechanisms. Besides, BVOC play an important rol
PurposeThis paper aims to examine how governance structures and actor dynamics shape knowledge integration in digital place innovation. Collaborative governance research emphasizes coordination and consensus-building, but less is known about how municipalities and private firms integrate heterogeneous knowledge systems when co-creating digital solutions for urban centers. Conceptualizing digital p
The aims of these studies were to evaluate retinoid measurements, more specifically the performance of all-trans and 13-cis retinoic acids methods in clinical experimental settings and to evaluate the informational value of these measurements in relation to S-Retinol. Biological and analytical variations for retinoids were evaluated for healthy subjects. The performance of the retinoic acid measur
