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Animal models of Parkinson’s disease and L-DOPA-induced dyskinesia are essential to explore pathophysiological hypotheses and to test new treatment options. There are many different animal models of Parkinson's disease, which differ greatly with respect to species, mechanisms of nigral cell death, and extent of dopamine-dependent motor deficits. My work has been performed in rats and mice with uni
I Den [o] hållbara förpackningen analyseras svenska konsumentförpackningar från 1930-talet fram till idag. Boken består av tre delar där läsaren först får lära känna mjölkförpackningarna, som är livsmedelsbranschens kanske vanligaste men samtidigt mest krävande förpackning. Därefter behandlas läkemedelsförpackningarna, en kategori som alltid har kännetecknats av ett högt säkerhetstänkande. Slutlig
In this dissertation I will discuss horror film as a genre and study how Hellraiser relates to its themes and problems. First I describe the production of the film and after that I present Clive Barker - his background, authorship, film-making and artwork. Next I study the problems of the genre and the different ways in which this genre is defined. I look at narrative characteristics as well as, f
There is a growing need for multifunctional polymeric materials for the development of several important energy conversion technologies. For example, the polymer electrolyte is a key component in lithium polymer batteries. The basic functions of this electrolyte are to efficiently conduct the lithium ions and physically separate the electrodes. Consequently, these electrolytes should ideally posse
The reuse and closed-loop recycling of food packaging was studied in order to assess consumer safety and the sensory quality (e.g. taste and smell) of packaged food. Polyethylene terephthalate (PET) beverage bottles that were refillable or that contained recycled material, either in direct contact or with a functional barrier protecting the food, were investigated with focus on odorous compounds f
In this thesis, the phylogenetic relationships of the Mammalia have been studied at various levels. Different sources of genetic information have been evaluated and used as phylogenetic markers. These include the well-known mitochondrial genome, cDNA from housekeeping genes and expressed sequence tags from nuclear genes. Applying RT-PCR on mRNA from nuclear genes is a new approach for collecting
The cyanoprokaryote (blue-green algae) genus Arthrospira occurs in saline, alkaline tropical waters of Africa, Asia, and Central America. Traditionally Arthrospira has been used as a food supplement by the Kanembu tribe of Lake Chad and Aztecs living in the valley of Mexico City. It is presently cultivated in large scale throughout the world and sold as a health food supplement due to its nutritio
Vascular smooth muscle can adapt to increased intraluminal pressure by remodelling and hypertrophy, as seen in hypertension. The molecular mechanisms responsible for this are still incompletely characterized. We have developed an organ culture system where strips of rat or mouse portal veins are cultured for 1 to 3 days loaded (stretched) by an attached weight and then studied for morphology, func
The biological response to different implanted biomaterials vary. The relative importance of factors in the material and host for this variation are at present incompletely known. The variation in the cellular response to specific proteins and the rapid adsorption of proteins to surfaces exposed to biological environments has created the hypothesis that the cellular interactions with biomaterials
The central phenomenon investigated concerns the valence-based process asymmetry found in several earlier studies (e.g. Pratto & John, 1991; Taylor, 1991), where negative stimuli seem to initiate more thorough processing than positive stimuli. This finding was consistent in the three empirical studies forming this dissertation. In Study 1 (three experiments) emotionally valenced words were pre
In this thesis the phenomenology of Quantum Chromo Dynamics (QCD) is studied in a variety of circumstances from both perturbative and non-perturbative perspectives. The main emphasis is on the production and hadronization of heavy particles, specifically heavy quarks, gauge bosons, leptoquarks and supersymmetric particles. In the hadroproduction of long-lived heavy quarks (i.e. charm and bottom)
This thesis is a study of how energy use and air pollution in Poland, Estonia, Latvia and Lithuania have been affected by the economic transition after 1989. It consists of six articles, which examine three different aspects of these changes. The first group of articles analyses the structure of energy use in the Baltic states (Article I) and Poland Articles II and III) at the outset of transitio
This thesis describes experiments performed using different methods to produce aerosol nanoparticles with control over size and composition. The process included differential mobility analyzers (DMAs) as size-selecting instruments and tube furnaces for particle synthesis. A method to estimate the degradation of the DMA performance from the ideal case for individual DMAs was proposed and tested ex
Vitreoscilla is an obligate aerobic bacterium living in oxygen-poor environments such as stagnant ponds and decaying vegetable matter. Vitreoscilla expresses a homodimeric haemoglobin (VHb) when subjected to oxygen-limited conditions. In several organisms, expression of VHb has been shown to increase microaerobic cell growth and enhance oxygen-dependent cell metabolism. Moreover, the presence of V
Nematophagous fungi possess various mechanisms for infecting nematodes, and are either obligate parasites or facultative saprophytes. Nematophagous fungi have a potential as biological control agents against plant- and animal-parasitic nematodes. Generally there has been little success in using these fungi in such a way, and one reason might be that too little is known about the ecology of the nem
This dissertation is a study of the Christian thematics in the novels of Christine Falkenland. It has two basic aims. First, to demonstrate how Christine Falkenland writes herself into, and becomes a distinct voice in, a Christian literary tradition, while simultaneously breaking with this tradition by staging and portraying modern people’s questioning of the Christian worldview. Second, to uncove
The interaction between murine bone marrow-derived dendritic cells (DC) and the Gram negative bacteria Salmonella typhimurium and Escherichia coli have been characterised. These studies showed that DC phagocytosed and processed S. typhimurium and E. coli expressing defined epitopes for peptide presentation on major histocompatibility complex class I (MHC-I) and class II (MHC-II) molecules. Process
Commonly cooked meat dishes contain heterocyclic amines (HAs) at ng/g levels. HAs are animal carcinogens, form DNA adducts in human tissues, and have been associated with increased risk of cancer in epidemiological studies, and it is thus recommended that human intake be decreased. The aim of this investigation was to find ways of modifying cooking practices to reduce the formation of HAs. Various
Approximately half of all women will sustain a fracture after the age of 50. Fractures may cause long-term disability and excess mortality. Identifying individuals at high risk of sustaining a fracture is important in the development of primary and secondary prevention strategies. In this study, initiated to identify factors associated with a high risk of future fractures, 1 044 women, all 75 yea
In this work, the synthesis and characterisation of new low-valence transition metal carbonyl clusters, and an investigation into their viability to act as catalysts/catalyst precursors in asymmetric synthesis, are described. Carbonyl clusters based on ruthenium and osmium have been tested as (pre)catalysts for asymmetric hydrogenation of alpha-unsaturated carboxylic acids, and cobalt carbonyl clu
