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Bone deficiencies, caused by malformations, trauma or adverse effects from medical treatments, are a clinical challenge and often associated with reduced physical function and quality of life. Autologeous bone grafts can be used to reconstruct skeletal defects, but the right size and quality of bone might not always be available and even so, donor-site morbidity might follow. A pre-fabricated or t
Melanoma is an aggressive disease that arises from deregulated signaling events in melanocytes. The KIT receptor tyrosine kinase and the Microphthalmia-associated transcription factor (MITF) are two essential components that are required for the normal physiology of melanocyte development and function. Consequently, aberrant activities of these factors are involved in the development of melanoma.
Hairdressers have an increased risk for developing airway symptoms e.g. asthma and rhinitis. Persulfate salts, which are oxidizing agents present in bleaching powder, are considered to be important causal agents for these symptoms. The underlying mechanisms are unclear and efficient tools for risk assessment and diagnosis are scarce. The general aim of this thesis was to measure proteomic changes,
Abdominal Aortic Aneurysms, AAA, is mainly a silent disease that mainly affects elderly males with a history of tobacco use, but when rupture occur most affected dies. Endovascular aneurysm repair (EVAR) has made it possible to treat more fragile and elderly patients with advanced co-morbidities. The benefit of EVAR might be questionable in relation to all cause mortality in some patients. Hence,
Although Physical Education (PE) is a part of the school curriculum in many countries, the association between the performance in PE and later morbidity is largely unknown. An important marker of health, cardiorespiratory fitness is inversely associated with future cardiovascular disease (CVD) and mortality. It has been suggested that muscle strength is associated in a similar way. However, whethe
Splitting methods are widely used as temporal discretizations of evolution equations. Such methods usually constitute competitive choices whenever a vector field can be split into a sum of two or more parts that each generates a flow easier to compute or approximate than the flow of the sum. In the research presented in this Licentiate thesis we consider dissipative evolution equations with vector
The two genetically related human lentiviruses known today, HIV-1 (which is pandemic) and HIV-2 (which mainly is confined to West Africa), are the causative agents of AIDS. Progressive immune dysfunction and AIDS develop in most cases of untreated HIV-1 infection, but only in approximately 25-30% of HIV-2 infected individuals. The V1-V3 region of the HIV-1 env gp120 is important for HIV-1 corecept
Background: A prognostic marker should provide information about course and outcome of disease, e.g. predict time to a given endpoint or rate of progression due to disease in patients or subgroups of patients. Prognostic markers could be targeted to apply during the entire clinical course or just during distinct stages of the disease. Aim: The aim of this thesis is to identify, review and qualif
Diesel engines are widely used as powertrain solutions for transportation vehicles. Their low fuel consumption and high performance make them attractive, however, their associated pollutant emissions is a major drawback which represent a hazard for public health and the environment. Therefore, the concentrations of the major pollutant species are regulated. Soot, which to a large extent consists
Cerebral arteries participate actively in the response that follows an episode of cerebral ischemia in man and rat. It has been shown that the vascular endothelin receptor expression is increased in stroke and organ culture. Furthermore, studies have demonstrated the intracellular signalling pathways, leading to the enhanced expression of vascular endothelin receptors. We have revealed that both c
The blood is composed of many different cell types that through tightly regulated mechanisms are derived from hematopoietic stem cells (HSCs). In addition, HSCs are able to undergo self-renewing divisions whereby new HSCs are produced. This is an extremely important feature of HSCs in order to ensure the existence of the HSC pool that is paramount to provide life-long hematopoiesis. Aging is in ge
Glioma is the most common type of primary tumor in the adult central nervous system (CNS). However, the current classification of gliomas is highly subjective and even inaccurate in some cases, which leads to clinical confusion and hinders the development of targeted therapies. EGFR and PDGFRA play crucial roles in glia development and glioma pathogenesis. In this thesis we aim to establish a glia
Abstract: Mammography is currently the established method in breast cancer screening, although the sensitivity is known be affected by overlapping tissue concealing tumours. Breast tomosynthesis takes advantage of multiple exposures at different angles reducing the negative effect of obscuring tissue. The aim of this thesis was to investigate the use of tomosynthesis in breast imaging with a spec
To understand the growth of continental crust, the balance between juvenile mantle derived extraction, infracrustal reworking and crustal recycling, needs to be estimated. Since the beginning of the century, the use of coupled in situ zircon U–Pb, Lu–Hf and O isotope analyses as a tool to address these questions have increased exponentially. Numerous compilations of ever growing datasets have been
Popular science Biogenic volatile organic compounds (BVOCs) are a versatile group of non-methane hydrocarbons (chemical compounds made of carbon and hydrogen) emitted by vegetation. The most common BVOCs from plants are some chemical compounds like isoprene, monoterpenes and sesquiterpenes. BVOCs are involved in plant growth, reproduction and defense mechanisms. Besides, BVOC play an important rol
My identity in the eyes of myself and others [translated title]. The purpose of this study was to examine how teenage girls experience their identities and how it is constructed and influenced by external factors. It was also an attempt to illustrate how mass media and social media like Facebook and blogs can be elements in the construction of identities. Berger and Luckmann‟s social construction
The external ventricular drain (EVD) is an important instrument in the management of neuro-intensive care patients through its ability to meassure intracranial pressure and to treat increased intracranial pressure by drainage of cerebrospinal fluid (CSF). However, EVDs are associated with the risk of external ventricular drain related infection (EVDRI). EVDRI diagnosis is challenging as symtoms an
This thesis concerns a numerical investigation on heat transfer in internal combustion engines, with the aim of increasing engine efficiency. The efficiency gains are to be extracted from reduced heat transfer losses, by increasing the knowledge on how the heat transfer process is affected by various hardware and operational parameters in the engine. The engines concerned are both conventional die
All natural populations fluctuate in space and time. These fluctuations are a result of internal dynamic processes, and of a variable environment. To understand how and why population fluctuate, one has to understand the nature of the internal demographic processes as well as how a variable environment affects these processes and how they act in concert to generate population fluctuations. This th
